研究动态
Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

组织和肿瘤的全基因组倍增。

Whole-genome doubling in tissues and tumors.

发表日期:2023 Sep 13
作者: Marc A Vittoria, Ryan J Quinton, Neil J Ganem
来源: PHARMACOLOGY & THERAPEUTICS

摘要:

绝大多数增殖的人体体细胞是二倍体的,而且这种基因组状态通常会在连续的细胞分裂中保持不变。然而,细胞分裂的失败可以引发整个基因组的倍增(WGD)事件,使二倍体细胞过渡到四倍体状态。虽然一些WGD是发育程序化的,用于产生具有特定细胞功能的非增殖性四倍体细胞,但是未预计的WGD事件可能是灾难性的:错误产生的四倍体细胞无法适应其加倍的细胞和染色体内容,并且很快变得基因组不稳定和形成肿瘤的。阐明支配整个基因组倍增(WGD+)细胞起源、生理和进化的遗传学可能揭示选择性消除病理WGD+细胞的治疗途径。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
The overwhelming majority of proliferating somatic human cells are diploid, and this genomic state is typically maintained across successive cell divisions. However, failures in cell division can induce a whole-genome doubling (WGD) event, in which diploid cells transition to a tetraploid state. While some WGDs are developmentally programmed to produce nonproliferative tetraploid cells with specific cellular functions, unscheduled WGDs can be catastrophic: erroneously arising tetraploid cells are ill-equipped to cope with their doubled cellular and chromosomal content and quickly become genomically unstable and tumorigenic. Deciphering the genetics that underlie the genesis, physiology, and evolution of whole-genome doubled (WGD+) cells may therefore reveal therapeutic avenues to selectively eliminate pathological WGD+ cells.Copyright © 2023 Elsevier Ltd. All rights reserved.