免疫应答中Granzyme B的成像与监测。
Imaging and monitoring of granzyme B in the immune response.
发表日期：2023 Sep 15
作者：
Xiangxia Li, Guiyuan Chen, Kecheng Wu, Haocheng Zheng, Zuotong Tian, Ze Xu, Weidong Zhao, Jianping Weng, Yuanzeng Min
来源：
Wires Nanomed Nanobi
摘要：
肿瘤免疫治疗领域取得了显著的进展，利用人体免疫反应杀灭和清除肿瘤细胞。然而，过度激活的免疫反应可能导致各种自身免疫性疾病和急性排斥反应。在这些过程中，对免疫反应进行准确而特异性的监测，有助于选择适当的治疗和方案，可降低副作用的风险。炎性细胞谷胱甘肽酶B(GzmB)是一种理想的免疫反应生物标志物，其肽底物可以与荧光染料或对比剂结合，用于合成由GzmB激活的成像探针。这些基于PET、生物发光成像或荧光成像的小分子和纳米探针已被证明具有很高的GzmB特异性和准确性。本综述总结了不同GzmB响应成像探针的设计及其在肿瘤免疫治疗和过度激活免疫反应监测中的应用。本文章被归类于：诊断工具 > 体内纳米诊断和成像。© 2023 Wiley Periodicals LLC.
Significant progress has been made in tumor immunotherapy that uses the human immune response to kill and remove tumor cells. However, overreactive immune response could lead to various autoimmune diseases and acute rejection. Accurate and specific monitoring of immune responses in these processes could help select appropriate therapies and regimens for the patient and could reduce the risk of side effects. Granzyme B (GzmB) is an ideal biomarker for immune response, and its peptide substrate could be coupled with fluorescent dyes or contrast agents for the synthesis of imaging probes activated by GzmB. These small molecules and nanoprobes based on PET, bioluminescence imaging, or fluorescence imaging have proved to be highly GzmB specific and accuracy. This review summarizes the design of different GzmB-responsive imaging probes and their applications in monitoring of tumor immunotherapy and overreactive immune response. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging.© 2023 Wiley Periodicals LLC.