口腔鳞状细胞癌中环状RNA的调控作用。
Regulatory role of circular RNAs in oral squamous cell carcinoma.
发表日期：2023 Aug 31
作者：
Rukset Attar, Khalida Noel, Mirna Azalea Romero, Uteuliyev Yerzhan Sabitaliyevich, Ishmuratova Margarita Yulaevna, Muhammad Zahid Qureshi
来源：
Disease Models & Mechanisms
摘要：
OSCC是一种基因组复杂的疾病，现代分子肿瘤学的发展使研究人员能够几乎完整地描绘信号网络的解析图。在过去的二十年里，压倒性的概念证明了非编码RNA在肿瘤发生中的机制调控作用，包括OSCC。环状RNA展示了肿瘤学研究中一个蓬勃发展的方面，分子生物学家们才刚刚开始意识到和认识到circRNAs在OSCC发病机制中的重要性。非编码RNA在重新塑造信号通路中的调节作用为预防/抑制OSCC提供了可行的策略。环状RNA在OSCC中起到了机制性的作用，更广泛的circRNA介导的"海绵效应"需要有理地针对性地作为有效的癌症预防目标进行靶向治疗。在不同类型的动物模型中进行的卓越和前沿的研究工作将进一步完善我们对最有前景的circRNA进行药理学上有价值的靶点选择的了解。
OSCC is a genomically complicated disease and advancements in the modern era of molecular oncology have enabled researchers to portray near-to-complete resolution of signaling landscape. Over the last two decades, overwhelming proof-of-concept has established mechanistic regulatory role of non-coding RNAs in carcinogenesis, including OSCC. Circular RNAs demonstrate a burgeoning facet of oncology research and molecular biologists are only beginning to appreciate and recognize the significance of circRNAs in the pathogenesis of OSCC. Regulatory roles of non-coding RNAs in the re-shaping of signaling pathways offer plausible strategies for prevention/inhibition of OSCC. Circular RNAs have mechanistic roles in OSCC and "sponge effects" mediated by a wider variety of circRNAs need to be rationally targeted for effective cancer prevention. Phenomenal and cutting-edge research works in different types of animal models will further refine our knowledge for selection of most promising circRNAs as pharmacologically valuable targets.