本研究旨在研究胃癌患者围手术期（T1）、手术后（T2）和术后第一天（T3）外周血CD4+CD25+FOXP3+调节性T细胞（Treg）占CD4+ T细胞的比例，探讨七氟醚和异丙酚麻醉对胃癌患者预后的影响。共招募了40例晚期胃癌患者，随机分为七氟醚组（S组）和异丙酚组（T组）。采用流式细胞仪分别检测T1、T2和T3期患者外周血中CD4+ T细胞中CD4+CD25+FOXP3+ Treg细胞的比例。与ⅡB期相比，ⅢA期和ⅢB期患者的T1、T2和T3期CD4+CD25+FOXP3+Treg细胞的比例增加。与T组相比，S组患者T2和T3期外周血中CD4+CD25+FOXP3+ Treg细胞的表达下降。结果表明，CD4+CD25+FOXP3+ Treg细胞的表达可能与胃癌的TNM分期有关，七氟醚具有比异丙酚更好的减轻术后免疫抑制作用的效果。七氟醚能有效降低胃癌患者T2和T3期外周血中CD4+CD25+FOXP3+ Treg细胞的表达水平，为选择胃癌患者手术麻醉药物提供了理论依据。

In this study, the proportion of CD4+CD25+FOXP3+ regulatory T (Treg) cells in CD4+ T cells in the peripheral blood of gastric cancer patients before anesthesia induction (T1), after surgery (T2) and the first day after surgery (T3) was studied to explore the effect of sevoflurane and propofol anesthesia on the prognosis of gastric cancer patients. Forty patients with advanced gastric cancer were recruited and randomly divided into the sevoflurane group (S group) and the propofol group (T group). Flow cytometry was used to detect the proportion of CD4+CD25+FOXP3+ Treg cells in CD4+ T cells in the peripheral blood of patients with T1, T2 and T3, respectively. Compared with stage ⅡB, the proportion of CD4+CD25+FOXP3+ Treg cells in T1, T2 and T3 of stage ⅢA and stage ⅢB patients was increased. Compared with the T group, the expression of CD4+CD25+FOXP3+ Treg cells in the peripheral blood of T2 and T3 in the S group was decreased. The results showed that the expression of CD4+CD25+FOXP3+ Treg cells might be related to the TNM stage of gastric cancer and sevoflurane could alleviate the inhibition of postoperative immune function more than propofol. Sevoflurane effectively reduced the expression level of CD4+CD25+FOXP3+ Treg cells in peripheral blood of T2 and T3 of patients with gastric cancer, providing the theoretical basis for the selection of surgical anesthetics for patients with gastric cancer.