癌症是全球人类死亡的主要原因之一。其中一种最常见的恶性肿瘤是乳腺癌，它是仅次于肺癌和胃癌的世界第三常见癌症。本研究旨在评估60名患有浸润性导管癌的女性患者的癌组织和非癌组织中组织分化诱导非蛋白编码RNA（TINCR）的表达水平。还研究了TINCR表达与患者临床特征之间的关系。为此，从乳腺癌患者的癌组织和非癌组织分别提取总RNA。然后使用RT Prime Script试剂将总RNA转化为cDNA。qRT-PCR定量TINCR表达水平，并通过配对t检验分析结果。此外，使用ROC曲线分析评估TINCR在乳腺癌肿瘤组织中的生物标记物能力。根据结果，与相邻的非癌组织相比，乳腺癌患者肿瘤组织中TINCR水平下降（P<0.001）。TINCR表达与乳腺癌肿瘤组织中的肿瘤大小和淋巴结转移呈负相关。总体而言，乳腺癌患者肿瘤组织中TINCR表达水平的降低表明其可以区分相邻的癌组织和非癌组织。此外，乳腺癌患者的大型肿瘤、淋巴结转移以及激素受体阳性亚组（A和B）中TINCR的表达水平较低。

Cancer is one of the leading causes of human death worldwide. One of the most common types of malignancy among women is breast cancer, which is the third most common cancer in the world after lung and stomach cancer. This study aimed to evaluate the expression level of Tissue Differentiation-Inducing Non-Protein Coding RNA (TINCR) in adjacent tumor and non-tumor tissues of 60 women with invasive ductal breast cancer. The relationship between TINCR expression and the clinical characteristics of patients has also been studied. For this purpose, total RNA was isolated from breast cancer patients' adjacent tumor and non-tumor tissue. RT Prime Script reagent was then used to convert total RNA to cDNA. The qRT-PCR quantified the TINCR expression level and analyzed the results by paired t-test. In addition, ROC curve analysis was used to evaluate the biomarker power of TINCR in breast cancer tumor tissues. According to the results, a decrease in the level of TINCR was obtained in the tumor tissue of breast cancer patients compared to the adjacent non-tumor tissue (P<0.001). TINCR expression was negatively correlated with tumor size and lymph node metastasis in breast cancer tumor tissue. In general, the decrease in the expression level of TINCR in the tumor tissue of breast cancer patients shows that its expression level can differentiate the adjacent tumor and non-tumor tissue from each other. In addition, TINCR has a lower expression level in breast cancer patients with large tumors, lymph node metastasis, and luminal subgroups A and B.