本研究的目标是根据不同治疗方法，描述哪些最小疾病活动（MDA）领域主要在银屑病性关节炎（psoriatic arthritis，PsA）患者中实现。此外，还评估了MDA的实现与不同治疗组之间的关联。我们对两个经纵向分析的PsA组进行了横断面分析。入选标准为：年龄≥18岁，诊断为PsA，至少稳定治疗6个月。根据治疗方案将患者分为不同的治疗组：组1：非甾体抗炎药（non-steroidal anti-inflammatory drugs，NSAIDs）/环氧酶2抑制剂（cyclooxygenase 2 inhibitors，COX2i）/类固醇；组2：传统合成疾病改善抗风湿药（conventional synthetic Disease-Modifying Anti-Rheumatic Drugs，csDMARDs）；组3：肿瘤坏死因子α抑制剂（tumor necrosis factor α inhibitors，TNFi）；组4：白细胞介素抑制剂（interleukin inhibitors，IL）12-23i或IL-23i；组5：IL-17抑制剂（IL-17i）；组6：磷酸二酯酶4抑制剂（phosphodiesterase 4 inhibitors，PD4i）。根据治疗方案评估每个组实现的领域。进行多元逻辑回归分析评估治疗组与MDA实现之间的关联。共纳入220例患者，并有45.8%实现了MDA。在所有治疗组中，首先实现的MDA领域为：体表面积≤3、肿胀关节计数≤1和利兹滑囊炎指数≤1，而较少实现的MDA领域为患者整体评估（Patient Global Assessment，PtgA）≤2 cm和视觉模拟痛苦评分≤1.5 cm。逻辑回归分析显示，3组和4组患者实现MDA的几率比较高。每个治疗组中，较少实现的MDA领域是患者整体评估和疼痛，表明“患者主导的领域”仍然是一个未满足的需求。由于研究设计和某些组别患者人数较少，无法明确确定基于治疗实现或未实现哪些MDA领域；但是，可能存在一些差异。如果更大规模、前瞻性研究证实了我们的初步结果，我们可以在PsA中朝向个体化/领域治疗方法迈进。© 2023. 作者。

The aim of this work is to characterize which Minimal Disease Activity (MDA) domains are mainly achieved, based on different treatments, in psoriatic arthritis (PsA) patients. Moreover, the association between MDA achievement and the different treatment groups was assessed.We conducted a cross-sectional analysis of two longitudinal PsA groups. Inclusion criteria were: age ≥ 18 years, PsA diagnosis, stable treatment for at least 6 months. Patients were grouped depending on the therapy: group 1: Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)/cyclooxygenase 2 inhibitors (COX2i)/steroids, group 2: conventional synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs), group 3: Tumor Necrosis Factor α  inhibitors (TNFi), group 4: interleukin inhibitors (IL)12-23i or IL-23i, group 5: IL-17i, group 6: phosphodiesterase 4 inhibitors (PD4i). For each group, the achieved domains based on therapy were assessed. Multivariate logistic regression analysis was performed to assess the association between the treatment groups and the MDA achievement.A total of 220 patients were enrolled, and MDA was achieved in 45.8% of them. In all treatment groups, the first MDA domains achieved were: body surface area ≤ 3, swollen joint count ≤ 1 and Leeds Enthesitis Index ≤ 1, while MDA domains less frequently achieved were Patient Global Assessment (PtgA) ≤ 2 cm and pain on visual analogue scale ≤ 1.5 cm. The logistic regression analysis showed higher odds ratios for the achievement of the MDA in those patients in groups 3 and 4.In each treatment group, MDA domains less frequently achieved were PtGA and pain, suggesting that "patient-driven domains" are still an unmet need. Due to the study design and the low number of patients in some groups, it is not possible to clearly define which MDA domain was achieved or not based on treatment; however, it seems that some differences could be present. If larger and prospective studies confirm our preliminary results, we could move toward a personalized/domain treatment approach in PsA.© 2023. The Author(s).