单分子树突状MRI纳米探针揭示依赖于大小的肿瘤进入。
Single-Molecule Dendritic Mri Nanoprobes Reveal the Size-Dependent Tumor Entrance.
发表日期：2023 Sep 16
作者：
Huiming Ren, Qiuhui Hu, Jiajia Yang, Xiaoxuan Zhou, Xiangrui Liu, Jianbin Tang, Hongjie Hu, Youqing Shen, Zhuxian Zhou
来源：
BIOMASS & BIOENERGY
摘要：
药物传递系统，包括治疗蛋白和纳米医学，的肿瘤入口在影响治疗结果方面起着至关重要的作用。纳米颗粒的大小是在血液循环、肿瘤积聚和穿透之间进行权衡的关键因素，但也是一种矛盾因素。在这里，我们设计了一系列具有明确定义的尺寸的单分子钆（Gd）基磁共振成像（MRI）纳米探针，以精确探索依赖于尺寸的肿瘤入口情况。通过分散合成获得的MRI纳米探针包含一个核心分子，该分子由宏观循环Gd（III）络合物和不同层次的树状赖氨酸单元组成，类似球形蛋白。我们发现，r1弛豫率和MR成像信号随着纳米颗粒尺寸的增大而增加。在大小临界值约为8.0 nm左右的纳米探针中，实现了更优的肿瘤积聚和穿透。这些单分子MRI纳米探针可用于精确地研究与尺寸相关的纳米颗粒生物相互作用。本文受版权保护。保留所有权利。
The tumor entrance of drug delivery systems, including therapeutic proteins and nanomedicine, plays an essential role in affecting the treatment outcome. Nanoparticle size is a critical but contradictory factor in making a trade-off among blood circulation, tumor accumulation, and penetration. Here, we designed a series of single-molecule gadolinium (Gd)-based magnetic resonance imaging (MRI) nanoprobes with well-defined sizes to precisely explore the size-dependent tumor entrance in vivo. The MRI nanoprobes obtained by divergent synthesis contain a core molecule of macrocyclic Gd(III)-chelate and different layers of dendritic lysine units, mimicking globular protein. We found that the r1 relaxivity and MR imaging signals increased with the nanoparticle size. The nanoprobe with a lower limit of critical size threshold around ∼8.0 nm achieved superior tumor accumulation and penetration. These single-molecule MRI nanoprobes can be served to precisely examine the size-related nanoparticle-biological interactions. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.