夜班工作、睡眠时长与子宫内膜癌风险：来自流行病学子宫内膜癌协作组（E2C2）的综合分析。
Night shift work, sleep duration and endometrial cancer risk: A pooled analysis from the Epidemiology of Endometrial Cancer Consortium (E2C2).
发表日期：2023 Sep 07
作者：
Jon Frias-Gomez, Laia Alemany, Yolanda Benavente, Megan A Clarke, Javier de Francisco, Immaculata De Vivo, Mengmeng Du, Marc T Goodman, James Lacey, Linda M Liao, Loren Lipworth, Lingeng Lu, Melissa A Merritt, Kara A Michels, Kelli O'Connell, Sonia Paytubi, Beatriz Pelegrina, Paula Peremiquel-Trillas, Stacey Petruzella, Jordi Ponce, Harvey Risch, Veronica Wendy Setiawan, Leo J Schouten, Xiao-Ou Shu, Britton Trabert, Piet A Van den Brandt, Nicolas Wentzensen, Lynne R Wilkens, Herbert Yu, Laura Costas
来源：
SLEEP MEDICINE REVIEWS
摘要：
子宫内膜癌发病的生物钟相关因素的数据稀缺。我们收集了11项参与流行病学子宫内膜癌联合研究（简称E2C2）的研究中，7,207例病例和22,027例对照个体关于夜班工作或每日睡眠时长的数据。主要分析针对绝经后妇女进行：6,335例子宫内膜癌病例和18,453例对照。使用个体数据，使用Logistic回归估计了各个研究特异性的比值比（OR）及其对应的95%置信区间（CI），并使用随机效应的荟萃分析进行了汇总分析。结果表明，子宫内膜癌与夜班工作之间呈非显著性负相关（OR=0.89, 95%CI=0.72-1.09; I2=0.0%, Pheterogeneity=0.676）。不同班次（固定或轮班）或夜班工作时长与子宫内膜癌的关系无差异。短睡眠时长（<7小时）或长睡眠时长（≥9小时）的分类与子宫内膜癌风险无关（ORshort=1.02,95%CI=0.95-1.10;I2=55.3%,Pheterogeneity=0.022;ORlong=0.93,95%CI=0.81-1.06;I2=11.5%,Pheterogeneity=0.339）. 睡眠时间每增加1小时与子宫内膜癌无关（OR=0.98,95%CI=0.95-1.01;I2=46.1%,Pheterogeneity=0.063）, 但在肥胖妇女中发现了逆相关（OR=0.93,95%CI=0.89-0.98每增加1小时;I2=12.7%,Pheterogeneity=0.329）。总体而言，这些汇总分析证实了绝经后妇女中夜班工作和睡眠时间对子宫内膜癌的风险影响不大。
Data on the role of circadian related factors in the etiology of endometrial cancer are scarce. We collected individual data on night shift work or daily sleep duration from 7,207 cases and 22,027 controls participating in 11 studies from the Epidemiology of Endometrial Cancer Consortium (E2C2). Main analyses were performed among postmenopausal women: 6,335 endometrial cancer cases and 18,453 controls. Using individual data, study-specific odd ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated with logistic regression and pooled analyses were conducted using random-effects meta-analyses. A non-significant inverse association was observed between endometrial cancer and night shift work (OR=0.89, 95%CI=0.72-1.09; I2=0.0%, Pheterogeneity=0.676). Associations did not vary by shift type (permanent or rotating), or duration of night work. Categorizations of short (<7h) or long (≥9h) sleep duration were not associated with endometrial cancer risk (ORshort=1.02, 95%CI=0.95-1.10; I2=55.3%, Pheterogeneity=0.022; ORlong=0.93, 95%CI=0.81-1.06; I2=11.5%, Pheterogeneity=0.339). No associations were observed per 1-h increment of sleep (OR=0.98, 95%CI=0.95-1.01; I2=46.1%, Pheterogeneity=0.063), but an inverse association was identified among obese women (OR=0.93, 95%CI=0.89-0.98 per 1-h increment; I2=12.7%, Pheterogeneity=0.329). Overall, these pooled analyses provide evidence that night shift work and sleep duration are not strong risk factors for endometrial cancer in postmenopausal women.Copyright © 2023 Elsevier Ltd. All rights reserved.