研究动态
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生物标志物在衰老和癌症中的联合应用 - 挑战与现状。

Combination of the biomarkers for aging and cancer? - Challenges and current status.

发表日期:2023 Sep 14
作者: Dai Li, Feng Ju, Han Wang, Chunfu Fan, Jule C Jacob, Sheraz Gul, Andrea Zaliani, Thomas Wartmann, Maria Cristina Polidori, Christiane J Bruns, Yue Zhao
来源: CLINICAL PHARMACOLOGY & THERAPEUTICS

摘要:

随着全球人口老龄化的加剧,被诊断为癌症患者的比例也在增加。高龄是老年人群发病率和死亡率的主要风险因素。由于个体健康状况随年龄而异,医学专业人员在癌症领域获得标准化的治疗结果面临挑战。因此,仅依赖于年龄和与疾病相关的参数对老年患者进行临床决策是不足够的。随着年龄增长,功能、多病症和心理社会变化的发生,肿瘤学疾病可能与年轻患者的发展和治疗方式有所不同,导致治疗疗效和耐受性上的独特挑战。个体化疗法使用生物标志物作为一个有前景的解决方案已经出现。各种类别的生物标志物,包括炎症、血液学、代谢学、内分泌和DNA修饰相关指标,可能显示与癌症和衰老相关的特征,有助于为老年癌症患者开发创新的治疗方法。此外,作为非分子表型生物标志物的身体功能测量正被研究其在结构化多领域对抗与年龄相关疾病(如癌症)中的潜在辅助作用。本综述提供了关于癌症和衰老生物标志物在当前发展、最新发现和重大挑战方面的见解,特别关注其在高龄环境中的应用。版权所有 © 2023。Elsevier Inc.出版。
The proportion of patients diagnosed with cancer has been shown to rise with the increasing aging global population. Advanced age is a major risk factor for morbidity and mortality in older adults. As individuals experience varying health statuses, particularly with age, it poses a challenge for medical professionals in the cancer field to obtain standardized treatment outcomes. Hence, relying solely on chronological age and disease-related parameters is inadequate for clinical decision-making for elderly patients. With functional, multimorbidity-related, and psychosocial changes that occur with aging, oncologic diseases may develop and be treated differently from younger patients, leading to unique challenges in treatment efficacy and tolerance. To overcome this challenge, personalized therapy using biomarkers has emerged as a promising solution. Various categories of biomarkers, including inflammatory, hematological, metabolic, endocrine, and DNA modification-related indicators, may display features related to both cancer and aging, aiding in the development of innovative therapeutic approaches for patients with cancer in old age. Furthermore, physical functional measurements as non-molecular phenotypic biomarkers are being investigated for their potential complementary role in structured multidomain strategies to combat age-related diseases such as cancer. This review provides insight into the current developments, recent discoveries, and significant challenges in cancer and aging biomarkers, with a specific focus on their application in advanced age.Copyright © 2023. Published by Elsevier Inc.