肿瘤脂类代谢：饮食与癌症进展之间的机制连接。
Tumor lipid metabolism: a mechanistic link between diet and cancer progression.
发表日期：2023 Sep 13
作者：
Yu-Jin Jeong, Thomas J Rogers, Carolyn E Anderson, Evan C Lien
来源：
CURRENT OPINION IN BIOTECHNOLOGY
摘要：
“抗癌饮食”对改变癌症风险和预后的潜力已经引起了病人、医生和研究人员的想象力，但是其中许多饮食建议都是基于相关性研究，将特定饮食与癌症风险的变化联系在一起。尽管引人注目，但我们对这些饮食干预对癌症进展的分子机制知之甚少。然而在这个背景下，肿瘤脂质代谢的变化正在被认为是一个关键因素。在本综述中，我们研究了肿瘤微环境（TME）中脂质代谢的当前理解，提出了饮食诱导的脂质组成变化如何调节肿瘤进展和治疗效果。通过剖析参与脂质代谢的各种细胞途径，我们强调了饮食如何调控肿瘤中饱和脂肪酸和不饱和脂肪酸物种的平衡，从而影响癌细胞和基质细胞的功能。最后，我们描述了当前癌症治疗如何与饮食相互作用，提高治疗效果。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
The potential for 'anti-cancer' diets to markedly alter cancer risk and prognosis has captured the imagination of patients, physicians, and researchers alike, but many of these dietary recommendations come from correlative studies that attribute certain diets to altered cancer risk. While provocative, little is known about the molecular mechanisms behind how these dietary interventions impact cancer progression. Within this context, however, changes in tumor lipid metabolism are emerging as a key contributor. In this review, we examine the current understanding of lipid metabolism in the tumor microenvironment (TME), suggesting how diet-induced changes in lipid composition may regulate tumor progression and therapeutic efficacy. By dissecting various cellular pathways involved in lipid metabolism, we highlight how diet modulates the balance between saturated and unsaturated fatty acid (FA) species in tumors to impact cancer cell and stromal cell function. Finally, we describe how current cancer therapies may synergize with diet to improve therapeutic efficacy.Copyright © 2023 Elsevier Ltd. All rights reserved.