在S期之外完成基因组复制。
Completing genome replication outside of S phase.
发表日期：2023 Sep 08
作者：
Rahul Bhowmick, Ian D Hickson, Ying Liu
来源：
MOLECULAR CELL
摘要：
有丝分裂DNA合成（MiDAS）是一种在有丝分裂期间发生的不寻常的DNA复制形式。最初，MiDAS被认为是与固有不稳定位点（常见脆性位点）相关的过程，这些位点在细胞经历DNA复制应激（RS）后发生。然而，现在认为它是一种更为广泛的“救援”机制，用于完成任何未复制的基因组区域的复制。新出现的数据表明，MiDAS可能是一个涉及两个或更多路径并行或顺序工作的DNA修复过程。在本综述中，我们介绍RS的原因、人类基因组中易受RS攻击的区域，以及在S期外完成DNA复制的策略。此外，由于MiDAS是非整倍体癌细胞的一个显著特征，我们将讨论如何靶向MiDAS可能会对癌症治疗产生改进。版权所有2023年该作者。由Elsevier Inc.出版。保留所有权利。
Mitotic DNA synthesis (MiDAS) is an unusual form of DNA replication that occurs during mitosis. Initially, MiDAS was characterized as a process associated with intrinsically unstable loci known as common fragile sites that occurs after cells experience DNA replication stress (RS). However, it is now believed to be a more widespread "salvage" mechanism that is called upon to complete the duplication of any under-replicated genomic region. Emerging data suggest that MiDAS is a DNA repair process potentially involving two or more pathways working in parallel or sequentially. In this review, we introduce the causes of RS, regions of the human genome known to be especially vulnerable to RS, and the strategies used to complete DNA replication outside of S phase. Additionally, because MiDAS is a prominent feature of aneuploid cancer cells, we will discuss how targeting MiDAS might potentially lead to improvements in cancer therapy.Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.