磷酸肌醇3-激酶作为治疗血管生成性疾病的靶点。
Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease.
发表日期：2023 Sep 14
作者：
Wenyi Wu, Xiaobo Xia, Luosheng Tang, Jing Luo, Siqi Xiong, Gaoen Ma, Hetian Lei
来源：
Stem Cell Research & Therapy
摘要：
磷酸肌醇3-激酶（PI3Ks）生成能够调控细胞存活和增殖的脂质，在细胞内发挥多种作用。此外，PI3K信号传导还对代谢、免疫、血管生成和心血管稳态以及许多疾病起重要作用。PI3K的多样作用源于其多种异构体的存在以及各种蛋白质效应器的参与。因此，PI3K异构体特异性抑制剂已经在治疗癌症方面取得了显著疗效。本文总结了PI3K抑制剂在防止血管通透性和新生血管生成中的分子机制。此外，我们还简要阐述了PI3K信号传导如何调节血管生长，并讨论了不同PI3K异构体在血管生成中的不同作用。版权所有 © 2023. 由Elsevier Ltd.出版。
Phosphoinositide 3-kinases (PI3Ks) generate lipids that control multitudinous intracellular cell signaling events which participate in cell survival and proliferation. In addition, PI3K signaling also contributes to metabolism, immunity, angiogenesis and cardiovascular homeostasis, and many diseases. The diverse actions of PI3K stem from the existence of their various isoforms and a variety of protein effectors. Hence, PI3K isoform-specific inhibitors have already achieved a wonderful effect on treating cancer. Herein, we summarize the molecular mechanism of PI3K inhibitors in preventing the permeability of vessels and neovascularization. Additionally, we briefly illustrate how PI3K signaling modulates blood vessel growth and discuss the different roles that PI3K isoforms play in angiogenesis.Copyright © 2023. Published by Elsevier Ltd.