关于细胞外基质对乳腺癌发生和进展的影响的最新研究进展。
Recent progress on the effect of extracellular matrix on occurrence and progression of breast cancer.
发表日期：2023 Sep 14
作者：
Tong-Yao Yu, Ge Zhang, Xiao-Xia Chai, Li Ren, Da-Chuan Yin, Chen-Yan Zhang
来源：
LIFE SCIENCES
摘要：
乳腺癌（BC）转移是针对BC治疗的巨大挑战。细胞外基质（ECM）作为BC转移巢穴的主要组成部分，是乳腺肿瘤发展的关键驱动因素，其生化和生物物理特性已经引起了广泛的关注。在本文中，我们回顾了ECM成分的生物学影响以及ECM刚度对BC转移和药物抗性的影响。我们概述了相关信号转导机制、现有的转移模型和以ECM刚度为中心的靶向药物策略。这将为探索更多底层靶点和开发以ECM为目标的特异性药物提供启示，这在乳腺癌治疗中具有潜力。版权所有 ©2023 Elsevier Inc. 发表。
Breast cancer (BC) metastasis is an enormous challenge targeting BC therapy. The extracellular matrix (ECM), the principal component of the BC metastasis niche, is the pivotal driver of breast tumor development, whose biochemical and biophysical characteristics have attracted widespread attention. Here, we review the biological effects of ECM constituents and the influence of ECM stiffness on BC metastasis and drug resistance. We provide an overview of the relative signal transduction mechanisms, existing metastasis models, and targeted drug strategies centered around ECM stiffness. It will shed light on exploring more underlying targets and developing specific drugs aimed at ECM utilizing biomimetic platforms, which are promising for breast cancer treatment.Copyright © 2023. Published by Elsevier Inc.