揭示Forkhead box转录因子D1在癌症中的多功能作用。
Dissecting multifunctional roles of forkhead box transcription factor D1 in cancers.
发表日期：2023 Sep 14
作者：
Lin Cheng, Haixu Yan, Yang Liu, Gefei Guan, Peng Cheng
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
摘要：
作为forkhead盒（FOX）转录因子（TF）家族的成员，FOXD1最近被认为是多种人类癌症中的关键调节因子。积累的证据已经表明，FOXD1信号的紊乱和异常是肿瘤发展和进展的显著特征。然而，目前对于这一主题缺乏系统性综述。在这里，我们总结了FOXD1在癌症生物学中的作用的现有认识，并在当前报告的背景下回顾了FOXD1的下游靶点和上游调控机制以及相关的信号通路。我们重点突出了FOXD1在癌症中的功能特点，以确定这一多功能转录因子的未来研究考虑和针对其致癌活性的潜在治疗策略。版权所有 © 2023 Elsevier B.V. 发表。
As a member of the forkhead box (FOX) family of transcription factors (TF), FOXD1 has recently been implicated as a crucial regulator in a variety of human cancers. Accumulating evidence has established dysregulated and aberrant FOXD1 signaling as a prominent feature in cancer development and progression. However, there is a lack of systematic review on this topic. Here, we summarized the present understanding of FOXD1 functions in cancer biology and reviewed the downstream targets and upstream regulatory mechanisms of FOXD1 as well as the related signaling pathways within the context of current reports. We highlighted the functional features of FOXD1 in cancers to identify the future research consideration of this multifunctional transcription factor and potential therapeutic strategies targeting its oncogenic activity.Copyright © 2023. Published by Elsevier B.V.