我们以前报道，饮食中常量摄入的黄烷酮寡聚体 + 聚合物和花青素与缺血性中风的风险较低有关。然而，没有研究调查它们与缺血性中风亚型之间的关系。在这个后续分析中，我们研究了黄烷酮寡聚体 + 聚合物和花青素的摄入量与缺血性中风亚型（包括1）大动脉粥样硬化、2）心源性栓塞、3）小血管闭塞、4）其他确定性病因和5）不确定性病因）的关系。从丹麦饮食、癌症和健康研究中选取了参与者（n=55,094），对其进行了长达16年的随访，观察首次缺血性中风事件，并按照急性中风治疗试验（TOAST）标准进行分类。使用Phenol-Explorer从食物频率问卷中计算黄烷酮寡聚体 + 聚合物和花青素的摄入量，并使用限制性立方样条函数和Cox比例风险模型研究它们与缺血性中风亚型之间的关系。在多变量调整后，习惯性摄入量较高（五分位数5与五分位数1之比）的黄烷酮寡聚体 + 聚合物和花青素与特定的缺血性中风亚型风险较低有关，包括大动脉粥样硬化[黄烷酮寡聚体 + 聚合物，HR (95%CI): 0.64 (0.47, 0.87)]、心源性栓塞[花青素，HR (95%CI): 0.45 (0.25, 0.82)]和小血管闭塞[黄烷酮寡聚体 + 聚合物，HR (95%CI): 0.65 (0.54, 0.80); 花青素，HR (95%CI): 0.79 (0.64, 0.97)]，但与其他具体确定或不确定病因的中风无关。习惯性摄入黄烷酮和花青素与动脉粥样硬化和/或心源性栓塞引起的缺血性中风的风险不同，但与其他亚型无关。 © 2023年 Elsevier Inc. 保留所有权利。

We previously reported habitual consumption of dietary flavanol oligomers + polymers and anthocyanins are associated with a lower risk of ischemic stroke. No studies, however, have investigated their relationship with ischemic stroke subtypes.In this follow-up analysis, we examine the association of flavanol oligomers + polymers and anthocyanin intake with ischemic stroke subtypes including 1) large-artery atherosclerosis, 2) cardioembolism, 3) small-vessel occlusion, 4) other determined etiology and 5) undetermined etiology.Participants (n=55,094) from the Danish Diet, Cancer, and Health Study, were followed for up to 16 years for first-time ischemic stroke events, which were classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Intakes of flavanol oligomers + polymers and anthocyanins were calculated from food frequency questionnaires using Phenol-Explorer and their relationships with ischemic stroke subtypes were investigated using restricted cubic splines within Cox proportional hazards models. After multivariable adjustment, higher habitual intakes (quintile 5 vs. quintile 1) of flavanol oligomers + polymers and anthocyanins were associated with lower risk of specific ischemic stroke subtypes including large-artery atherosclerosis [flavanol oligomers + polymers, HR (95%CI): 0.64 (0.47, 0.87)], cardioembolism [anthocyanins, HR (95%CI): 0.45 (0.25, 0.82)], and small-vessel occlusion [flavanol oligomers + polymers, HR (95%CI): 0.65 (0.54, 0.80); anthocyanins, HR (95%CI): 0.79 (0.64, 0.97)], but not stroke of other determined or undetermined etiology.Higher habitual intakes of flavanols and anthocyanins are differentially associated with lower risk of ischemic stroke from atherosclerosis and/or cardioembolism, but not with other subtypes.Copyright © 2023. Published by Elsevier Inc.