Selenoproteins和tRNA-Sec：癌症氧化还原平衡的调控因子。
Selenoproteins and tRNA-Sec: regulators of cancer redox homeostasis.
发表日期：2023 Sep 14
作者：
Stephen L DeAngelo, Balázs Győrffy, Markos Koutmos, Yatrik M Shah
来源：
ANTIOXIDANTS & REDOX SIGNALING
摘要：
在过去的二十年中，人们已经取得了关于硒生物功能的重要进展。硒是一种必需的微量元素，它被用于硒胱氨酸的生物合成，并被嵌入到硒蛋白中。这些硒蛋白已经成为细胞抗氧化能力和氧化还原平衡维持的中央调节因子。本综述全面检查了硒蛋白多方面功能，特别强调了它们对细胞抗氧化能力的贡献。此外，我们还着重介绍了定向靶向硒蛋白和硒胱氨酸生物合成的治疗干预癌症的潜在前景。通过了解硒、硒蛋白和活性氧（ROS）之间的复杂关系，可以获得有益的启示，以开发利用癌细胞固有易损性的治疗方法。版权所有 © 2023 Elsevier Inc. 保留所有权利。
In the past two decades significant progress has been made in uncovering the biological function of selenium. Selenium, an essential trace element, is required for the biogenesis of selenocysteine which is then incorporated into selenoproteins. These selenoproteins have emerged as central regulators of cellular antioxidant capacity and maintenance of redox homeostasis. This review provides a comprehensive examination of the multifaceted functions of selenoproteins with a particular emphasis on their contributions to cellular antioxidant capacity. Additionally, we highlight the promising potential of targeting selenoproteins and the biogenesis of selenocysteine as avenues for therapeutic intervention in cancer. By understanding the intricate relationship between selenium, selenoproteins, and reactive oxygen species (ROS), insights can be gained to develop therapies that exploit the inherent vulnerabilities of cancer cells.Copyright © 2023 Elsevier Inc. All rights reserved.