在这项研究中，我们开发了一种基于二硫化钼（MoS2）的递送系统，使用聚乙二醇（PEG）和生物素进行功能化，并同时装载Curcumin（Cur）和erlotinib（Er），以实现高效的抗癌治疗。MoS2-PEG-Biotin-Cur/Er系统能够有效地将近红外（NIR）光转化为热能，从而诱导癌细胞的光热消融，并促进Cur和Er的控制释放。生物素介导的肿瘤靶向作用促进了MoS2-PEG-Biotin-Cur/Er在肿瘤部位的选择性积聚，从而增强了Cur和Er的协同抗肿瘤效果。值得注意的是，经过合成的MoS2-PEG-Biotin-Cur/Er在近红外光照射下实现了协同化疗和光热疗法（PTT）的结合，有效抑制了肺癌细胞的增殖并抑制了体内肿瘤生长。由于具有高靶向能力、近红外光响应性药物释放以及协同化疗和光热疗法的综合应用，这种合成的MoS2-PEG-Biotin-Cur/Er递送系统在临床实践中可能提供一种有前景的肺癌治疗策略。© 2023. 生物医学中央有限公司，施普林格自然出版集团的一部分。

Curcumin (Cur), a bioactive component of Chinese traditional medicine, has demonstrated inhibitory properties against cancer cell proliferation while synergistically enhancing the anticancer efficacy of erlotinib (Er). However, the individual limitations of both drugs, including poor aqueous solubility, lack of targeting ability, short half-life, etc., and their distinct pharmacokinetic profiles mitigate or eliminate their combined antitumor potential.In this study, we developed a molybdenum disulfide (MoS2)-based delivery system, functionalized with polyethylene glycol (PEG) and biotin, and co-loaded with Cur and Er, to achieve efficient cancer therapy. The MoS2-PEG-Biotin-Cur/Er system effectively converted near-infrared (NIR) light into heat, thereby inducing direct photothermal ablation of cancer cells and promoting controlled release of Cur and Er. Biotin-mediated tumor targeting facilitated the selective accumulation of MoS2-PEG-Biotin-Cur/Er at the tumor site, thus enhancing the synergistic antitumor effects of Cur and Er. Remarkably, MoS2-PEG-Biotin-Cur/Er achieved the combination of synergistic chemotherapy and photothermal therapy (PTT) upon NIR irradiation, effectively suppressing lung cancer cell proliferation and inhabiting tumor growth in vivo.The as-synthesized MoS2-PEG-Biotin-Cur/Er, featuring high targeting ability, NIR light-responsive drug release, and the integration of synergistic chemotherapy and PTT, may provide a promising strategy for the treatment of lung cancer in clinical practice.© 2023. BioMed Central Ltd., part of Springer Nature.