评估Integra®双层创面矩阵（Integra）在口腔缺损重建中的可行性、安全性和失败率。回顾性队列研究。所有研究信息均来自一家单一的学术三级医院。研究对象包括2015年至2020年间在MD Anderson癌症中心接受口腔切除和即时重建的成年患者，使用Integra®双层创面矩阵。收集以下变量：患者人口统计学资料、合并症、疾病分期、治疗和重建方式以及医疗记录中的手术结果。统计分析包括对所有收集参数进行分布分析以及使用Pearson's χ2检验找出变量与Integra的接受率之间的相关性。83名患者采用Integra®双层创面矩阵进行重建。平均年龄为66岁。39名患者（47%）有先前接受口腔肿瘤切除的病史。14名患者（17%）有头颈部放疗史。最常见的病理类型是侵袭性鳞状细胞癌（75%），其次是异常增生（12%）。83名患者（96%）完全愈合，并且细胞完美融合，只有3例失败需要额外手术。下颌切除缺损重建与脱垂和骨暴露的风险增加相关（0.66，P = .03）。本研究显示出Integra®双层创面矩阵在不同口腔缺损重建中具有较高的接受率，我们鼓励外科医生将此技术作为可行且多功能的选择加入到口腔缺损重建的方法中。© 2023 The Authors. otolaryngology-Head and Neck Surgery由Wiley Periodicals LLC代表American Academy of Otolaryngology-Head and Neck Surgery Foundation发布。

To evaluate the feasibility, safety, and failure rate of Integra® Bilayer Wound Matrix (Integra) in the reconstruction of oral cavity defects.Retrospective cohort study.All study information was collected from a single academic tertiary care hospital.Subjects included adult patients who underwent oral cavity resection and immediate subsequent reconstruction with Integra® Bilayer Wound Matrix at MD Anderson Cancer Center between the years 2015 and 2020. The following variables were collected: patient's demographics, comorbidities, disease stage, treatment and reconstruction modalities, and surgical outcome from the medical records. Statistical analysis included distribution analysis for all collected parameters and Pearson's χ2 tests to find correlation between variables and take rate of Integra.Eighty-three patients underwent reconstruction with Integra® Bilayer Wound Matrix dressing. Average age was 66 years old. Thirty-nine patients (47%) had history of previous resections for oral cavity tumors. Fourteen patients (17%) had history of radiation therapy to the Head and Neck region. Most common pathology was invasive squamous cell carcinoma (75%) followed by dysplasia (12%). Complete wound healing with good cellular integration occurred in 83 patients (96%) with only 3 failures requiring additional surgery. Reconstruction of mandibulectomy defects was associated with increased risk of dehiscence and bone exposure (0.66, P = .03).This study shows promising results with high take rate of Integra® Bilayer Wound Matrix dressing in the reconstruction of various oral cavity defects. We encourage surgeons to adopt this technique as a viable and versatile option into the reconstruction ladder of oral cavity defects.© 2023 The Authors. Otolaryngology-Head and Neck Surgery published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology-Head and Neck Surgery Foundation.