口腔鳞癌（OSCC）发展的早期阶段未经通知或不可区分，是口腔癌晚期检测和预后不良的主要原因。本综述总结了有关失调非编码RNA（ncRNA）对细胞周期的影响以及其作为口腔癌的诊断和预后生物标志物的可应用性的先前研究和最新进展。我们使用以下关键词进行了文献搜索：“血清/唾液非编码RNA”和“血清/唾液非编码RNA和细胞周期”，“血清/唾液失调ncRNAs和细胞周期”，“Cdk/CKI和ncRNAs”，以及涉及“口腔癌”的“组织ncRNAs”。编制的数据主要关注微小RNA（miRNAs）、环状RNA（circRNAs）和长非编码RNA（lncRNAs）在口腔癌和其他癌症以及与主题相关的非英语文章中的诊断和预后意义。此外，不包括在研究中重点关注DNA、蛋白质和代谢物标记的文章。虽然在体液中存在DNA、RNA、蛋白质、代谢物和特定抗原等多种潜在生物分子作为口腔癌的预测生物标志物，但本综述完全关注限定在唾液和血液中的非编码RNA，并根据先进技术、队列和敏感性以及特异性挑选出一些可靠的生物分子，即唾液中的miR-1307-5p、miR-3928、hsa_circ_0001874和ENST00000412740，以及循环中的NR_131012、ENST00000588803、NR_038323、miR-21。因此，需要进一步研究以在口腔癌的临床上确认这些非侵入性生物标志物的应用。 © 2023. 作者在Springer Nature B.V.的独家许可下发布

The unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and cell cycle', 'serum/saliva dysregulated ncRNAs and cell cycle', 'Cdk/CKI and ncRNAs', 'tissue ncRNAs' concerning 'oral cancer''. The compiled data focuses mainly on the diagnostic and prognostic significance of MicroRNAs (miRNAs), Circular RNAs (circRNAs), and Long noncoding RNAs (lncRNAs) on oral cancer and all other cancers as well as subject-relevant articles published in languages other than English are beyond the scope of this review and excluded from the study. Moreover, articles focusing on DNA, protein, and metabolite markers are eliminated from the study. While there exist various potential biomolecules such as DNA, RNA, proteins, metabolites, and specific antigens representing predictive biomarkers in body fluids for oral cancer, this review completely focuses on non-coding RNAs restricted to saliva and blood, picking out a few of the reliable ones amongst the recent investigations based on the sophisticated techniques, cohort, and sensitivity as well as specificity, i.e., salivary miR-1307-5p, miR-3928, hsa_circ_0001874 and ENST00000412740, NR_131012, ENST00000588803, NR_038323, miR-21 in circulation. Thus, further studies are required to clinically confirm the usage of these non-invasive biomarkers in oral cancer.© 2023. The Author(s), under exclusive licence to Springer Nature B.V.