本实践声明的目标是帮助成员及其多学科团队在临床环境中识别输液反应和过敏反应。它将提供建议，以指导对反应的回应和恰当时的脱敏疗法，以促进所有提供者在化疗药物使用过程中的安全使用。来自妇科肿瘤学协会教育委员会的一支多学科医疗团队共同合作，通过审查同行评审的文献和指南，制定了关于化疗过敏反应和脱敏方案的实践声明。 在治疗妇科癌症过程中，患者对任何药物都有可能发生反应，可能发生输液反应和过敏反应。应在最常见与反应相关的治疗方案中的输液前至少给予预防反应的预处理。在发生反应时，由于症状和体征的相似性，很难区分输液反应和真正的过敏反应，因此非常重要的是每份化疗医嘱中都包含处理反应的指示，以便输液护士可以在等待医护人员评估患者的同时立即采取干预措施。脱敏疗法是一种允许患者继续接受致敏药物的潜在选择。尽管文献中提出了各种脱敏方案，但目标是减少步骤和变异性，以减少化疗制备或给药过程中出现的错误机会。 结合SGO教育委员会的文献评述和临床经验，本文概述了妇科癌症常用化疗药物的预防和管理反应的当前方法。 版权所有© 2023 Elsevier Inc. 保留所有权利。

The goal of this practice statement is to help members and their multidisciplinary teams recognize infusion reactions and hypersensitivity reactions in the clinical setting. It will provide recommendations to help guide response to reactions and desensitization when appropriate, to promote safe use of chemotherapeutic agents among all providers in the delivery process.A multi-disciplinary team of healthcare professionals from the Society of Gynecologic Oncology Education Committee collaborated to review peer reviewed literature and guidelines to develop a practice statement on the management of chemotherapy hypersensitivity reactions and desensitization regimens.There is always potential for a patient to have a reaction to any medication, with both infusion reactions and hypersensitivity reactions potentially occurring in the treatment of gynecologic cancers. Premedication to prevent reactions should be given at least prior to infusion for regimens that include the most common agents associated with reactions. At the time when reaction is occurring it might be difficult to distinguish between an infusion reaction versus true hypersensitivity given the similarities in signs and symptoms, therefore it is important that orders to manage reactions be included in every chemotherapy order set so the infusion nurse can provide immediate interventions while waiting for the provider to arrive to assess the patient. Desensitization is a potential option to allow the patient to continue to receive the offending agent. While a variety of desensitization regimens have been presented in the literature, the goal is to minimize steps and variability to decrease opportunity for errors during chemotherapy preparation or administration.Incorporating a review of the literature and clinical experience from the SGO Education Committee, this paper provides an overview of current approaches for prevention and management of reactions to commonly used chemotherapy agents for gynecologic cancers.Copyright © 2023 Elsevier Inc. All rights reserved.