针对肿瘤内缺氧来增强抗肿瘤免疫力。
Targeting intratumoral hypoxia to enhance anti-tumor immunity.
发表日期：2023 Sep 15
作者：
Gregg L Semenza
来源：
SEMINARS IN CANCER BIOLOGY
摘要：
癌症通过表达大量基因来建立免疫抑制性肿瘤微环境。其中许多基因是通过缺氧诱导而表达的，缺氧诱导因子HIF-1和HIF-2通过转录激活介导此过程。本综述总结了最近几份研究报告，描述了缺氧诱导对肉瘤、乳腺癌、结直肠癌、肝细胞癌、前列腺癌和子宫癌等免疫逃逸机制。这些研究指出了几种新的治疗方法，可以改善抗肿瘤免疫和增加对免疫疗法的反应。版权所有 © 2023 Elsevier Ltd. 保留所有权利。
Cancers express a large battery of genes by which they establish an immunosuppressive tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through transcriptional activation mediated by hypoxia-inducible factors HIF-1 and HIF-2. This review summarizes several recent reports describing hypoxia-induced mechanisms of immune evasion in sarcoma and breast, colorectal, hepatocellular, prostate and uterine cancer. These studies point to several novel therapeutic approaches to improve anti-tumor immunity and increase responses to immunotherapy.Copyright © 2023 Elsevier Ltd. All rights reserved.