姜黄素是一种从中药植物姜黄（Curcuma longa）中提取的天然草药和多酚。其抗菌、抗炎、抗癌、抗突变、抗氧化和抗真菌性质可以用来治疗各种口腔和全身性疾病。然而，自然姜黄素具有溶解度低、生物利用度有限和迅速降解的问题，从而严重限制了其治疗潜力。为了克服这些缺点，已经开发了纳米姜黄素（nCur）配方，用于改进生物材料传递和增强治疗效果。这种新颖的生物材料对于治疗各种口腔疾病具有巨大的潜力，其中大多数由于牙周生物膜引起。这些包括龋齿、牙周病、根管感染和周围植入物疾病，以及其他非生物膜介导的口腔疾病，如口腔癌和口腔扁平苔藓。一些体外研究已经表明，nCur在各种配方中对常见口腔病原菌（如变形链球菌、牙龈炎原唾液计算机和消化道链球菌）的抗菌效力。对于分别与龋齿、牙周炎和根管感染强相关的疾病，此外，一些临床研究说明nCur确实可以增强牙周炎和口腔扁平苔藓等口腔疾病的临床结果，但由于研究数量不足和现有研究的方法学局限性，临床证据的水平非常低。nCur治疗各种口腔疾病的多功能性对其在牙科学中的未来前景非常有利，这也反映在科学文献中有关该主题的研究迅速增加的速度。为了跟上nCur在牙科学中的最新发展，我们进行了本综述。本综述的目的是提供化学、性质、作用机制和科学证据更新与nCur在牙科学中的使用。版权所有 © 2023 Elsevier Inc 发表。

Curcumin is a natural herb and polyphenol that is obtained from the medicinal plant Curcuma longa. It's anti-bacterial, anti-inflammatory, anti-cancer, anti-mutagenic, antioxidant and antifungal properties can be leveraged to treat a myriad of oral and systemic diseases. However, natural curcumin has weak solubility, limited bioavailability and undergoes rapid degradation, which severely limits its therapeutic potential. To overcome these drawbacks, nanocurcumin (nCur) formulations have been developed for improved biomaterial delivery and enhanced treatment outcomes. This novel biomaterial holds tremendous promise for the treatment of various oral diseases, the majority of which are caused by dental biofilm. These include dental caries, periodontal disease, root canal infection and peri-implant diseases, as well as other non-biofilm mediated oral diseases such as oral cancer and oral lichen planus. A number of in-vitro studies have demonstrated the antibacterial efficacy of nCur in various formulations against common oral pathogens such as S. mutans, P. gingivalis and E. faecalis, which are strongly associated with dental caries, periodontitis and root canal infection, respectively. In addition, some clinical studies were suggestive of the notion that nCur can indeed enhance the clinical outcomes of oral diseases such as periodontitis and oral lichen planus, but the level of evidence was very low due to the small number of studies and the methodological limitations of the available studies. The versatility of nCur to treat a diverse range of oral diseases augurs well for its future in dentistry, as reflected by rapid pace in which studies pertaining to this topic are published in the scientific literature. In order to keep abreast of the latest development of nCur in dentistry, this narrative review was undertaken. The aim of this narrative review is to provide a contemporaneous update of the chemistry, properties, mechanism of action, and scientific evidence behind the usage of nCur in dentistry.Copyright © 2023. Published by Elsevier Inc.