在各种人类癌症中高度表达的环状RNA蛋白激酶C-ι（circPRKCI）据报道在癌症的发展和进展中起重要作用。因此，我们的目的是揭示circPRKCI在不同人类癌症中的表达的预后和临床价值。我们从Pubmed，Web of Science和Cochrane图书馆数据库开始搜寻，截至2021年5月16日。通过合并风险比（HR）和相应的95%置信区间（CI）评估circPRKCI表达与癌症患者生存，包括总生存期（OS）和无病生存期（DFS）之间的关系。使用相应的95% CI评估circPRKCI表达与临床结果之间的相关性。数据通过STATA软件（版本12.0）或Review Manager（RevMan 5.3）进行分析。总共纳入了1109名患者的15项研究进行了我们的荟萃分析。结果显示，与各种人类癌症低circPRKCI表达相比，高circPRKCI表达与较差的OS显着相关（HR = 1.96，95% CI：1.61，2.39，P <0.001）。然而，高circPRKCI表达与DFS无关（HR = 1.34，95% CI：0.93，1.95，P = 0.121）。此外，高circPRKCI表达的患者更容易出现较大的肿瘤大小，进展期临床分期和淋巴结转移，但与年龄，性别和远处转移无显著相关。高circPRKCI表达与较差的OS和不利的临床特征相关，提示circPRKCI在不同人类癌症中具有新的预后和预测作用。Copyright © 2023 The Chinese Medical Association，由Wolters Kluwer，Inc.根据CC-BY-NC-ND许可证制作。

Highly expressed in various human cancers, circular RNA Protein Kinase C Iota (circPRKCI) has been reported to play an important role in cancer development and progression. Herein, we sought to reveal the prognostic and clinical value of circPRKCI expression in diverse human cancers.We searched the Pubmed, Web of Science, and the Cochrane Library databases from inception until May 16, 2021. The relationship between circPRKCI expression and cancer patients' survival, including overall survival (OS) and disease-free survival (DFS), was assessed by pooled hazard ratios (HR) with corresponding 95% confidence interval (CI). The correlation between circPRKCI expression and clinical outcomes was evaluated using odds ratios (OR) with corresponding 95% CI. The data were analyzed by STATA software (version 12.0) or Review Manager (RevMan 5.3).A total of 15 studies with 1109 patients were incorporated into our meta-analysis. The results demonstrated that high circPRKCI expression was significantly related to poor OS (HR = 1.96, 95% CI: 1.61, 2.39, P <0.001) when compared with low circPRKCI expression in diverse human cancers. However, elevated circPRKCI expression was not associated with DFS (HR = 1.34, 95% CI: 0.93, 1.95, P = 0.121). Furthermore, the patient with a higher circPRKCI expression was prone to have a larger tumor size, advanced clinical stage, and lymph node metastasis, but it was not significantly correlated with age, gender, and distant metastasis.Elevated circPRKCI expression was correlated with worse OS and unfavorable clinical features, suggesting a novel prognostic and predictive role of circPRKCI in diverse human cancers.Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.