肿瘤免疫微环境在脊索瘤中的作用：充满希望的免疫疗法策略。
The role of tumor immune microenvironment in chordoma: promising immunotherapy strategies.
发表日期：2023
作者：
Jiuhui Xu, Qianyu Shi, Boyang Wang, Tao Ji, Wei Guo, Tingting Ren, Xiaodong Tang
来源：
Bone & Joint Journal
摘要：
脊索瘤是一种罕见的恶性骨肿瘤，治疗选择有限，对传统化疗和放疗有抵抗性，靶向治疗的疗效也较低。由于对其发生和发展机制的研究长期延迟，导致了缺乏有效的治疗靶点和临床可用药物的困境。近年来，在肿瘤研究领域，肿瘤免疫微环境在推动肿瘤生长方面的作用成为一个热门而具有挑战性的课题。免疫治疗在各种肿瘤治疗中显示出有希望的结果。然而，对脊索瘤免疫微环境的研究仍处于起步阶段。在本综述中，我们旨在全面揭示先前对脊索瘤免疫微环境的探索，并基于这些特点提出有希望的脊索瘤免疫治疗策略。版权所有 © 2023 Xu, Shi, Wang, Ji, Guo, Ren, and Tang.
Chordoma is a rare malignant bone tumor with limited therapeutic options, which is resistant to conventional chemotherapy and radiotherapy, and targeted therapy is also shown with little efficacy. The long-standing delay in researching its mechanisms of occurrence and development has resulted in the dilemma of no effective treatment targets and no available drugs in clinical practice. In recent years, the role of the tumor immune microenvironment in driving tumor growth has become a hot and challenging topic in the field of cancer research. Immunotherapy has shown promising results in the treatment of various tumors. However, the study of the immune microenvironment of chordoma is still in its infancy. In this review, we aim to present a comprehensive reveal of previous exploration on the chordoma immune microenvironment and propose promising immunotherapy strategies for chordoma based on these characteristics.Copyright © 2023 Xu, Shi, Wang, Ji, Guo, Ren and Tang.