尿道膀胱癌是一种与吸烟和职业相关的疾病，已经成为多个全基因组关联研究（GWAS）的研究对象。然而，基于GWAS结果对该病程进行区分肌肉侵袭性膀胱癌（MIBC）和非肌肉侵袭性膀胱癌（NMIBC）的研究还比较少见。因此，我们调查了4个在GWAS中检测到的单核苷酸多态性（SNP），与编码蛋白质TACC3（转化性酸性螺旋桨蛋白3）、FGFR3（成纤维细胞生长因子受体3）、PSCA（前列腺干细胞抗原）和编码蛋白质CBX6（染色体盒同源物6）和APOBEC3A（类胆固醇载脂蛋白B mRNA编辑酶催化亚单位样品） 的基因相关。这项研究基于德国3个不同病例对照研究中的712个膀胱癌患者和875个对照个体。通过实时聚合酶链反应确定了4个感兴趣的SNP（PSCA rs2294008和rs2978974，FGFR3-TACC3 rs798766以及CBX6-APOBEC3A rs1014971）。在整个研究群体和3个地区子群体中（包括两个曾经发达的工业区和一个没有此类历史的地区），这4个SNP的分布在病例和对照组之间没有显著差异。此外，在MIBC和NMIBC的膀胱癌亚组中也没有观察到显著差异。这4个研究的SNP对于MIBC和NMIBC膀胱癌亚组的风险没有显著不同的贡献。版权所有© 2023 Kadhum等人。

Urinary bladder cancer, a smoking and occupation related disease, was subject of several genome-wide association studies (GWAS). However, studies on the course of the disease based on GWAS findings differentiating between muscle invasive bladder cancer (MIBC) and non-muscle invasive bladder cancer (NMIBC) are rare. Thus we investigated 4 single nucleotide polymorphisms (SNPs) detected in GWAS, related to the genes coding for TACC3 (transforming, acidic coiled-coil containing protein 3), for FGFR3 (fibroblast growth factor receptor 3), for PSCA (prostate stem cell antigen) and the genes coding for CBX6 (chromobox homolog 6) and APOBEC3A (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A). This study is based on 712 bladder cancer patients and 875 controls from 3 different case control studies in Germany. The 4 SNPs of interest (PSCA rs2294008 and rs2978974, FGFR3-TACC3 rs798766, and CBX6-APOBEC3A rs1014971) were determined by real-time polymerase chain reaction. The distribution of the 4 SNPs does not vary significantly between cases and controls in the entire study group and in the 3 local subgroups, including two former highly industrialized areas and a region without such history. Also, no significant differences in the bladder cancer subgroups of MIBC and NMIBC were observed. The 4 investigated SNPs do not noticeably contribute differently to the bladder cancer risk for the bladder cancer subgroups of MIBC and NMIBC.Copyright © 2023 Kadhum et al.