研究动态
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天然存在的大黄素对于控制宫颈癌的抗癌作用。

Anticancer action of naturally occurring emodin for the controlling of cervical cancer.

发表日期:2023
作者: Priyanka S Lande, Vaibhav S Adhao, Jaya P Ambhore, Kiran P Gaikwad, Chanchal S Chandak, Leena P Joge
来源: Cell Death & Disease

摘要:

全球死亡的主要原因之一是癌症。全球女性第四常见恶性肿瘤是宫颈癌。尽管癌症研究在过去几十年取得了显著进展,但由于药物耐药性的出现,有些癌症患者仍然无法治愈。自然来源作为潜在的治疗候选物的重要性可能非常重大。蒽醌是许多天然产物化学家族之一,以其广泛的结构变化、显著的生物活性和低毒性而脱颖而出。一种名为大黄素的天然物质,即一种蒽醌衍生物,存在于多种植物的根和根茎中。这种物质已经表现出抗肿瘤、抗炎、抗血管生成和抗增殖的特性。它还能防止癌症扩散,并能逆转癌细胞的多药耐药性。大黄素是一种广谱的癌细胞抑制剂,在许多不同类型的生物途径中具有抗癌作用。这些在癌细胞中的分子机制包括抑制细胞生长和增殖、破坏细胞周期阻滞、启动凋亡、抗转移和抗血管生成的影响。因此,本综述的目的是总结大黄素在宫颈癌中的抗增殖和抗癌特性。© 作者(们) 2023年。
One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergence of medication resistance, despite notable advances in cancer research over the previous few decades. The importance of natural sources as possible therapeutic candidates may be significant. Anthraquinones are one of the many chemical families of natural products, and they stand out for their wide range of structural variations, notable biological activity, and low toxicity. A natural substance called emodin, an anthraquinone derivative, is present in the roots and rhizomes of several plants. This substance has demonstrated antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative properties. It is also capable of preventing cancer spread and can reverse cancer cells' multidrug resistance. Emodin, a broad-spectrum inhibitor of cancer cells, have anticancer properties in many different types of biological pathways. These molecular mechanisms in cancer cells include the suppression of cell growth and proliferation, deterioration of the cell cycle arrest, the start of apoptosis, antimetastasis, and antiangiogenic impact. Therefore, the aim of the present review summarised the antiproliferative and anticarcinogenic qualities of cervical cancer of emodin.© The Author(s) 2023.