近年来，在癌症治疗中的适配体取得了重要进展。
Recent Advancements of Aptamers in Cancer Therapy.
发表日期：2023 Sep 12
作者：
Swathi Venkatesan, Kaushik Chanda, Musuvathi Motilal Balamurali
来源：
Immunity & Ageing
摘要：
富勒烯是一种经化学修饰后具有克服传统抗体限制的化学抗体，尤其适用于癌症的诊断、治疗和治疗诊断应用。化学修饰或功能化（包括与核酸、药物分子和纳米粒子共轭结合）的便利性使这些富勒烯在研究中获得优先权。本综述讨论了各种关于富勒烯功能化纳米材料的疗法的报告，如受控或多步骤药物释放、靶向递送、刺激响应药物释放等。在核酸共轭富勒烯的情况下，讨论了DNA纳米管和DNA信标在化疗和基因治疗中多药物装载的可能性。此外，还讨论了电化学富勒烯传感器和信号增强的免疫富勒烯传感器的发展。进一步讨论了富勒烯技术在癌症治疗诊断中的未来前景和现有限制。© 2023 American Chemical Society发表的论文。
Aptamers are chemical antibodies possessing the capability of overcoming the limitations posed by conventional antibodies, particularly for diagnostic, therapeutic, and theranostic applications in cancer. The ease of chemical modifications or functionalization, including conjugations with nucleic acids, drug molecules, and nanoparticles, has made these aptamers to gain priorities in research. In this Mini-review, various reports on therapeutics with aptamer-functionalized nanomaterials for controlled or multistep drug release, targeted delivery, stimuli-responsive drug release, etc. are discussed. In the case of nucleic-acid-conjugated aptamers, DNA nanotrains and DNA beacons are discussed in terms of the possibility of multidrug loading for chemotherapy and gene therapy. Developments with electrochemical aptasensors and signal-enhanced immune aptasensors are also discussed. Further, the future scope of aptamer technology in cancer theranostics and the prevailing limitations are discussed.© 2023 The Authors. Published by American Chemical Society.