通过脂质包被的单原子金纳米酶增强氧化应激对口腔癌光动力疗法的作用
Amplification of oxidative stress by lipid surface-coated single-atom Au nanozymes for oral cancer photodynamic therapy.
发表日期：2023 Sep 18
作者：
Ming-Hsien Chan, Bo-Gu Chen, Chien-Hsiu Li, Wen-Tse Huang, Ting-Yi Su, Lichang Yin, Michael Hsiao, Ru-Shi Liu
来源：
MEDICINE & SCIENCE IN SPORTS & EXERCISE
摘要：
单原子纳米酶（SANs）是生物材料研究的最新趋势，促进了单原子在生物领域的应用和无机纳米颗粒中的蛋白质催化实现。碳量子点（CDs）作为携带单原子的底物具有优异的生物相容性和荧光特性。使用量子点作为载体突破单原子材料的纯相形式非常困难。此外，在口腔癌的单原子领域，尤其是头颈部鳞状细胞癌方面目前还没有相关研究。本研究开发了一种脂质表面包被的纳米酶，结合了CDs、单原子金和修饰的脂质配体（DSPE-PEG），并且使用转铁蛋白（Tf）来治疗口腔鳞状细胞癌。研究结果表明，表面修饰的单原子碳量子点（m-SACDs）具有出色的治疗效果，并可用于原位图像跟踪，以诊断和治疗头颈部鳞状细胞癌（HNSCC）。
Single-atom nanozymes (SANs) are the latest trend in biomaterials research and promote the application of single atoms in biological fields and the realization of protein catalysis in vivo with inorganic nanoparticles. Carbon quantum dots (CDs) have excellent biocompatibility and fluorescence properties as a substrate carrying a single atom. It is difficult to break through pure-phase single-atom materials with quantum dots as carriers. In addition, there is currently no related research in the single-atom field in the context of oral cancer, especially head and neck squamous cell carcinoma. This research developed a lipid surface-coated nanozyme combined with CDs, single-atomic gold, and modified lipid ligands (DSPE-PEG) with transferrin (Tf) to treat oral squamous cell carcinoma. The study results have demonstrated that surface-modified single-atom carbon quantum dots (m-SACDs) exhibit excellent therapeutic effects and enable in situ image tracking for diagnosing and treating head and neck squamous carcinoma (HNSCC).