基于合成的CuCo2O4纳米片，制备了一种用于检测肌氨酸的电化学捕获传感器。
Fabrication of an electrochemical aptasensor for the determination of sarcosine based on synthesized CuCo2O4 nanosheets.
发表日期：2023 Sep 18
作者：
Somayeh Farokhi, Mahmoud Roushani, Zahra Saedi
来源：
BIOSENSORS & BIOELECTRONICS
摘要：
尿液中肌氨酸（SRN）的检测与前列腺癌的诊断相关。然而，由于体液中SRN的浓度较低，SRN生物传感器的发展受到了限制。本文报道了一种新的电化学策略，用于选择性和准确地测定尿液样品中的SRN。合成了CuCo2O4纳米片（CuCo2O4 NSs）并将其用作前列腺癌诊断高效电化学适配体传感器的新平台。据我们所知，迄今为止尚未使用CuCo2O4 NSs设计电化学适配体传感器。CuCo2O4 NSs存在于电极表面作为平台，改善了传导性和表面积。因此，可以非常有效地改善电化学适配体传感器的诊断性能。该策略的线性浓度范围和检测限（LOD）分别计算为1 pM-8 μM和350 fM。
Sarcosine (SRN) detection in body fluids is related to the diagnosis of prostate cancer. However, the development of SRN biosensors has been limited due to the low concentration of SRN in body fluids. Here, a new electrochemical strategy for selective and accurate determination of SRN in urine samples is reported. CuCo2O4 nanosheets (CuCo2O4 NSs) have been synthesized and used as a new platform in the design of efficient electrochemical aptasensors for prostate cancer diagnosis. As far as we know, CuCo2O4 NSs have not been used so far in electrochemical aptasensor design. The presence of CuCo2O4 NSs on the electrode surface as a platform improves the conductivity and surface area. Therefore, it can be very effective in improving the diagnostic performance of the electrochemical aptasensor. The linear concentration range and limit of detection (LOD) for this strategy were calculated to be 1 pM- 8 μM and 350 fM, respectively.