肺侵袭性真菌病:超声和计算机断层扫描发现。
Pulmonary Invasive Fungal Disease: Ultrasound and Computed Tomography Scan Findings.
发表日期:2023 Sep 18
作者:
Seyed Ali Alamdaran, Raha Bagheri, Seyedeh Fatemeh Darvari, Elham Bakhtiari, Ali Ghasemi
来源:
Stem Cell Research & Therapy
摘要:
超声波在诊断肺侵袭性真菌病(IFD)中的重要性尚未得到评估。因此,本研究旨在评估怀疑侵袭性肺真菌感染的患者中超声波检查结果的频率。本前瞻性纵向研究检查了2019年至2022年期间所有转诊至谢赫和阿克巴儿科医院进行肺部病变影像学检查并怀疑IFD的患者。考虑的变量包括计算机断层扫描(CT)中的光晕征象;超声和造影CT扫描中的靶征象;腔和楔形浓缩;以及胸膜炎和胸壁外肺外侵袭或膈下侵袭两种影像学指标。所有进行肺部CT扫描和超声检查直至最终诊断的患者均进行了随访。评估超声和CT扫描结果的一致性程度以及这些征象的敏感性、特异性和诊断准确性。
本研究共涉及40名患者,平均年龄为7.16 ± 4.23岁。急性白血病是最常见的潜在疾病,在17例(42.5%)病例中检测到。在IFD患者中,超声中的靶征象(61.9%)和CT扫描中的光晕征象(71.4%)在变量中具有最高的频率。腔变量的Cohen's kappa系数在两种影像学方法中为0.5,与之具有显著相关性(P = .02)。对于其他发现,Cohen's kappa小于0.17(P> .05)。超声中真菌靶与CT扫描中的光晕在同时检查中的诊断标准显示其敏感性分别为82.4%和特异性为76.5%。
将超声和CT扫描的特征性发现结合起来,能提供更高的诊断价值,用于诊断肺侵袭性真菌病。
The importance of ultrasound in diagnosing pulmonary invasive fungal diseases (IFD) has yet to be assessed. Thus, this study aimed to evaluate the frequency of sonographic findings in patients suspected of an invasive pulmonary fungal infection.This prospective longitudinal study examined all patients with lung lesions in imaging modalities and suspected IFDs referred to Dr. Sheikh and Akbar pediatric hospitals from 2019 to 2022. Considered variables were the halo sign in the computed tomography (CT) scan; the target sign in the ultrasound and contrast-enhanced CT scan; the cavity; wedge-shaped consoli- dation; and pleuritis and extrapulmonary invasion to the chest wall or subdiaphragmatic invasion in both modalities. All patients who underwent lung CT scans and ultrasounds until the final diagnosis were followed up. The degree of agreement between ultrasound and CT scan findings and the sensitivity, specificity, and diagnostic accuracy of these signs were assessed.This study involved 40 patients with an average age of 7.16 ± 4.23 years. Acute leukemia was the commonest underlying dis- ease detected in 17 (42.5%) cases. The target sign in ultrasound (61.9%) and the halo sign in CT scan (71.4%) had the highest frequency among the variables in patients with IFD. Cohen's kappa coefficient agreement in both modalities was 0.5 for the cavity, with significant relation (P = .02). The Cohen's kappa was less than .17 for other findings (P > .05). The diagnostic criteria in the simultaneous examina- tion of the fungus target in ultrasound and halo in CT scan showed a sensitivity of 82.4% and specificity of 76.5%, respectively.Combining the characteristic findings of ultrasound and CT-scan provides a higher value in diagnosing pulmonary invasive fungal disease.