日晒对皮肤有害，增加了皮肤衰老和皮肤癌的风险。我们在这里研究了日常暴露于太阳辐射对皮肤微生物组的影响，以确定皮肤微生物菌可以对太阳损伤提供保护。我们采集了十名救生员在夏季前后的皮肤拭子，以分析皮肤微生物组。结果表明，在季节性日晒后，特定的皮肤微生物菌种得到了富集。尤其有趣的是两个细菌家族——Sphingomonas和红细菌科——它们可能具有对紫外线辐射提供保护的能力，因为它们产生潜在的保护化合物。我们集中研究了一种Sphingomonas菌株，并且证明它对紫外线照射高度抵抗，并能够降低人角质细胞中的活性氧生成物水平。这些结果初步证实了皮肤微生物组在太阳辐射防护中的作用。版权所有©2023年。由Elsevier Masson SAS出版。

Sun exposure is harmful to the skin and increases the risk of skin aging and skin cancer. Here we examined the effects of daily exposure to sun radiation on the skin microbiome in order to determine whether skim microbiome bacteria can contribute to protection from solar damage. Skin swabs were collected from ten lifeguards before and after the summer to analyse the skin microbiome. The results indicates that specific skin microbiome bacteria were enriched following the seasonal sun exposure. Especially interesting were two bacterial families - Sphingomonas and Erythrobacteraceae - which may have the ability to protect against UV radiation as they produce potentially protective compounds. We concentrated on a Sphingomonas strain and could show that it was highly resistant to UV irradiation and was able to reduce reactive oxygen species levels in human keratinocytes. These results provide a proof-of-concept for the role of the skin microbiome in protection from solar radiation.Copyright © 2023. Published by Elsevier Masson SAS.