胸膜弥漫性间皮瘤（DPM）是一种非常侵袭性的恶性新生物，起源于衬覆胸膜表面的间皮细胞。虽然DPM是一种被认可与石棉暴露相关的疾病，但最新的进展扩展了我们对其分子发病机制的理解，并改变了我们的临床实践。本综述全面探讨了DPM的当前概念和新兴趋势，包括风险因素、病理生物学、组织学亚型和治疗管理，强调多学科综合治疗这种复杂疾病的方法。《病理学年度评论：疾病机制》第19卷的最终在线出版日期预计为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates以获取修订后的预估日期。

Diffuse pleural mesothelioma (DPM) is a highly aggressive malignant neoplasm arising from the mesothelial cells lining the pleural surfaces. While DPM is a well-recognized disease linked to asbestos exposure, recent advances have expanded our understanding of molecular pathogenesis and transformed our clinical practice. This comprehensive review explores the current concepts and emerging trends in DPM, including risk factors, pathobiology, histologic subtyping, and therapeutic management, with an emphasis on a multidisciplinary approach to this complex disease. Expected final online publication date for the Annual Review of Pathology: Mechanisms of Disease, Volume 19 is January 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.