一名患有肺腺癌IV期的55岁男性患者接受了顺铂、培美曲塞、尼伐替尼和伊匹单抗治疗。治疗开始大约100天后，他变得精神错乱，并前往急诊就诊，出现高烧。血液检查显示肝功能和肾功能异常。随后，患者发生了全身性惊厥，需要重症监护。临床诊断为细胞因子释放综合征（CRS）和免疫效应细胞相关的神经毒性综合征（ICANS）。通过使用免疫抑制药物，包括类固醇，逐渐控制了器官损伤，患者获得了出院。在固体肿瘤免疫检查点抑制剂治疗期间，患有CRS，包括ICANS的患者的成功治疗是罕见的。

A 55-year-old man with stage IV lung adenocarcinoma was treated with cisplatin, pemetrexed, nivolumab, and ipilimumab. Approximately 100 days after treatment initiation, he became disoriented and presented to the emergency department with a high fever. Blood tests revealed liver and kidney dysfunctions. Subsequently, the patient developed generalized convulsions that required intensive care. He was clinically diagnosed with cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Organ damage was gradually controlled with immunosuppressive drugs, including steroids, and the patient was discharged. Successful treatment is rare in patients with CRS, including ICANS, during immune checkpoint inhibitor treatment for solid tumors.