胶质瘤是最常见的脑肿瘤，具有复杂的异质性。胶质瘤的基因、分子和组织病理学特征是神经炎症高度存在。中枢神经系统(CNS)的炎症微环境与控制炎症反应并协调固有免疫防御的炎症小体密切相关。炎症小体功能紊乱导致异常炎症反应，进而在胶质瘤发生过程中引发癌变。考虑到炎症小体在胶质瘤中各种生理特性的临床重要性，炎症小体被提出作为胶质瘤管理的有前景的治疗靶点。在这里，我们总结了炎症小体在胶质瘤中的贡献和治疗见解的当前认知。视频摘要。©2023。Springer Nature旗下BioMed Central有限公司。

Gliomas are the most common brain tumors characterized by complicated heterogeneity. The genetic, molecular, and histological pathology of gliomas is characterized by high neuro-inflammation. The inflammatory microenvironment in the central nervous system (CNS) has been closely linked with inflammasomes that control the inflammatory response and coordinate innate host defenses. Dysregulation of the inflammasome causes an abnormal inflammatory response, leading to carcinogenesis in glioma. Because of the clinical importance of the various physiological properties of the inflammasome in glioma, the inflammasome has been suggested as a promising treatment target for glioma management. Here, we summarize the current knowledge on the contribution of the inflammasomes in glioma and therapeutic insights. Video Abstract.© 2023. BioMed Central Ltd., part of Springer Nature.