正常分化的细胞主要依赖于线粒体氧化磷酸化来提供能量，但大多数肿瘤细胞依赖于无氧糖酵解。这种现象被称为"Warburg效应"。磷酸甘油酸激酶1(PGK1)是无氧糖酵解中的关键酶。PGK1参与葡萄糖代谢以及多种生物活动，包括血管生成、EMT、介导的自噬启动、线粒体代谢、DNA复制和修复等与肿瘤发生和发展相关的过程。最近，越来越多的研究证明PGK1在癌症中扮演着重要角色。本文讨论了PGK1调控癌症发生和进展的结构、功能、分子机制的效应。此外，PGK1与肿瘤患者的化疗抗药性和预后相关。本综述展示了PGK1在肿瘤发生中的不同角色，这将有助于设计涉及PGK1的实验研究，并增强PGK1作为肿瘤治疗靶点的潜力。视频摘要。© 2023. BioMed Central Ltd., Springer Nature的一部分。

Cells that undergo normal differentiation mainly rely on mitochondrial oxidative phosphorylation to provide energy, but most tumour cells rely on aerobic glycolysis. This phenomenon is called the "Warburg effect". Phosphoglycerate kinase 1 (PGK1) is a key enzyme in aerobic glycolysis. PGK1 is involved in glucose metabolism as well as a variety of biological activities, including angiogenesis, EMT, mediated autophagy initiation, mitochondrial metabolism, DNA replication and repair, and other processes related to tumorigenesis and development. Recently, an increasing number of studies have proven that PGK1 plays an important role in cancer. In this manuscript, we discussed the effects of the structure, function, molecular mechanisms underlying PGK1 regulation on the initiation and progression of cancer. Additionally, PGK1 is associated with chemotherapy resistance and prognosis in tumour patients. This review presents an overview of the different roles played by PGK1 during tumorigenesis, which will help in the design of experimental studies involving PGK1 and enhance the potential for the use of PGK1 as a therapeutic target in cancer. Video Abstract.© 2023. BioMed Central Ltd., part of Springer Nature.