血清和糖皮质激素诱导激酶1（SGK1）是一种可能在缺血再灌注（I/R）损伤和心肌功能障碍中起重要作用的酶。虽然已经进行了许多关于单个抗氧化剂的研究，但鲜有研究关注抗氧化剂与SGK1抑制剂联用对I/R后心脏功能的影响。本研究旨在确定没食子酸（作为抗氧化剂）与SGK1抑制剂联用对I/R诱导的心脏功能障碍和炎症的影响。将60只雄性Wistar大鼠随机分为6组，以没食子酸或车剂预处理10天，随后离体提取心脏并暴露于I/R。在接受SGK1抑制剂的组中，心脏在缺血诱导前5分钟与SGK1抑制剂GSK650394灌流。随后，评估心脏功能、炎症因子和心肌损伤。两种化合物的联合应用显著改善了心脏收缩能力、心率、收缩力产品、左心室舒张压、左心室收缩压、灌注压和QRS电压（P < 0.05）。此外，这两种药物的联合治疗降低了肿瘤坏死因子-alpha和白细胞介素-6的水平，以及肌酸激酶-MB、乳酸脱氢酶和肌钙蛋白I的活性（P < 0.05）。结果表明，没食子酸和SGK1抑制剂的联合应用可能对改善心脏功能障碍和I/R诱导的炎症具有增强效应。

Serum and glucocorticoid-induced kinase 1 (SGK1) is an enzyme that may play an important role in ischemic-reperfusion (I/R) injury and myocardial dysfunction. Although many studies have been conducted on individual antioxidants, little attention has been paid to the effects of co-administration of an antioxidant with an SGK1 inhibitor on cardiac function after I/R.This study aimed to determine the effects of gallic acid (as an antioxidant) combined with an SGK1 inhibitor on I/R-induced cardiac dysfunction and inflammation. Sixty male Wistar rats were randomized into 6 groups, pretreated with gallic acid or vehicle for 10 days. Subsequently, the heart was isolated and exposed to I/R. In groups that received the SGK1 inhibitor, the heart was perfused with the SGK1 inhibitor GSK650394, 5 min before induction of ischemia. After that, cardiac function, inflammatory factors, and myocardial damage were evaluated.The combination of these two compounds improved cardiac contractility, heart rate, rate pressure product, left ventricular developed pressure, left ventricular systolic pressure, perfusion pressure, and QRS voltage significantly (P < 0.05). In addition, concomitant therapy of these two agents reduced tumor necrosis factor-alpha and interleukin-6, and the activity of creatine kinase-MB, lactate dehydrogenase, and troponin-I (P < 0.05).The results indicated that administration of gallic acid with the SGK1 inhibitor may have a potentiating effect on the improvement of cardiac dysfunction and I/R-induced inflammation.