本文提出了一种独特的56岁患者左腿平滑肌肉瘤（Leiomyosarcoma，LMS）的个案。该患者在就医前约八个月经历了疼痛和肿块的问题。通过免疫组织化学（Immunohistochemistry，IHC）染色，诊断性活检显示多核异形细胞以交叉束状排列，针对波形蛋白（Vimentin）、平滑肌薄和（Caldesmon）以及平滑肌肌动蛋白（Smooth muscle actin）进行染色呈阳性。在四肢罹患LMS的罕见性强调了需要进一步了解和研究，以确定最适合此类患者的治疗方法。在这个具体案例中，患者接受了肿瘤切除手术，随后使用巨型假体进行重建。本报告强调了在处理四肢罕见的肿瘤如LMS时考虑独特的治疗策略的重要性。随着医学知识的不断发展，对这类病例的最佳管理的深入了解对于改善患者预后和总体预后非常重要。版权所有 © 2023, Kumar Yadav et al.

The paper at hand presents a unique case of leiomyosarcoma (LMS) involving the left leg in a 56-year-old patient. This individual experienced pain and the presence of a mass for approximately eight months before seeking medical attention. A diagnostic biopsy revealed the presence of multinucleated pleomorphic cells arranged in intersecting fascicles upon immunohistochemistry (IHC) staining for vimentin, caldesmon, and smooth muscle actin. The rarity of LMS in the extremities highlights the need for further understanding and research to determine the most suitable treatment approaches for such patients. In this specific case, the patient underwent tumor excision followed by reconstruction using a megaprosthesis. This report emphasizes the importance of considering unique treatment strategies when dealing with rare neoplasms like LMS in the extremities. As medical knowledge continues to evolve, gaining insights into the optimal management of such cases will be crucial for improving patient outcomes and overall prognosis.Copyright © 2023, Kumar Yadav et al.