来自远处原发恶性肿瘤的腮腺转移是罕见的，对临床医生来说具有诊断挑战。我们报道了一位65岁男性病例，他曾患肾透明细胞亚型癌，并出现了右腮腺区域无痛性肿块。他的病史中有一个右侧肾细胞癌，五年前他接受了根治性肾切除术。患者的体格检查发现右腮腺区域有一个坚实的非痛性肿块。影像学检查，包括超声和增强计算机断层扫描，证实了腮腺内有一个实质增强的病变。细针穿刺活检提供了与透明细胞肾细胞癌亚型一致的恶性细胞的组织学证据。这与腮腺转移性肾细胞癌的诊断一致。该病例强调了在腮腺肿块的鉴别诊断中考虑到转移性疾病的重要性，特别是在具有远期恶性肿瘤病史的患者中。靶向治疗，使用酪氨酸激酶抑制剂，被证明是一种有效的治疗选择，强调了在处理罕见临床情境中的个体化方法的重要性。个体化管理对于优化腮腺转移患者的结局、改善其整体预后和生活质量至关重要。版权所有©2023年，Aljawad等。

Parotid gland metastases from distant primary malignancies are uncommon and present diagnostic challenges for clinicians. We present the case of a 65-year-old male with a history of clear cell subtype of renal cell carcinoma who presented with a painless swelling in the right parotid region. His medical history was significant for a right-sided renal cell carcinoma, for which he had undergone a radical nephrectomy five years ago. The patient's physical examination revealed a firm, non-tender mass in the right parotid gland region. Imaging studies, including ultrasound and contrast-enhanced computed tomography, confirmed the presence of a solid-enhancing lesion within the parotid gland. Fine-needle aspiration biopsy provided histological evidence of malignant cells with features consistent with a clear renal cell carcinoma cell subtype. This is consistent with diagnosing metastatic renal cell carcinoma to the parotid gland. This case highlights the significance of considering metastatic disease in the differential diagnosis of parotid swellings, particularly in patients with a history of remote malignancy. Systemic targeted therapy, with a tyrosine kinase inhibitor, emerged as an effective treatment option, emphasizing the importance of personalized approaches in managing rare clinical scenarios. Tailored management is crucial in optimizing outcomes for patients with parotid gland metastases, improving their overall prognosis and quality of life.Copyright © 2023, Aljawad et al.