从非酒精性脂肪性肝炎到肝细胞癌的肿瘤形成。
Tumorigenesis from non-alcoholic steatohepatitis to hepatocellular carcinoma.
发表日期：2022 Dec
作者：
Junjie Yu, Utpal B Pajvani
来源：
Immunity & Ageing
摘要：
非酒精性脂肪性肝炎（NASH）伴随代谢综合征日益成为肝细胞癌（HCC）的主要原因。然而，NASH诱导HCC的肿瘤发生机制仍不清楚。在这个观点中，我们将讨论近期在理解HCC的遗传变化和免疫微环境方面取得的进展，以及尚待解答的问题。根据目前的研究，NASH-HCC可能具有新的机制，在未来需要进行更多的调查。© 2022作者，由德格鲁伊特出版，柏林/波士顿发表。
Non-alcoholic steatohepatitis (NASH) with metabolic syndrome is increasing to be a main cause of hepatocellular carcinoma (HCC). However, the mechanism of tumorigenesis in NASH induced HCC is still not clear. In this perspective, we will discuss the recent progress that has been made to understand the genetic change and the immune microenvironment of HCC, and the remaining questions. Based on the current study, NASH-HCC is likely to have novel mechanism, which needs more investigation in future.© 2022 the author(s), published by De Gruyter, Berlin/Boston.