目的：探讨血小板淋巴细胞比值（PLR）、红细胞分布宽度与血小板计数比值（RPR）以及全身性免疫炎症指数（SII）在卵巢子宫内膜囊肿的分期和术后复发中的预测价值。方法：对2018年1月至2020年1月期间在青岛大学附属医院接受腹腔镜手术治疗卵巢囊肿的患者的临床数据进行回顾性分析。手术后经病理证实为卵巢子宫内膜异位囊肿的患者为观察组（n=350），其他良性卵巢囊肿的患者为对照组（n=150）。记录两组患者术前的血小板计数、血小板分布宽度、中性粒细胞绝对数、淋巴细胞绝对数、单核细胞绝对数、红细胞分布宽度以及血清癌胚抗原125（CA125），计算并分析PLR、中性粒细胞淋巴细胞比值（NLR）、RPR、SII和全身炎症反应指数（SIRI）。统计所有患者的一般资料和观察组手术后2年内的随访资料，评估PLR、RPR和SII对卵巢子宫内膜囊肿的诊断价值以及手术后2年内的分期和复发预测价值。结果：观察组的PLR、NLR、SII（中位数分别为147.53、1.86和488.70）和CA125（中位数为59.41 kU/L）均显著高于对照组，而RPR（中位数为0.16）低于对照组，差异显著（均P<0.01）。两组SIRI无显著差异（P>0.05）。与Ⅰ期和Ⅱ期患者相比，观察组Ⅲ期和Ⅳ期患者的PLR、SII（中位数分别为122.73、345.00）较高，而RPR较低，差异显著（均P<0.001）。术后2年内复发患者的PLR、NLR、SII、SIRI（中位数分别为179.63、2.75、762.96、1.06）和CA125（中位数为108.83 kU/L）均显著高于无复发患者，差异显著（均P<0.001）。CA125在卵巢子宫内膜异位囊肿诊断中的曲线下面积（AUC）为0.951，敏感性为85.7%，特异性为93.0%，高于PLR和SII；PLR+SII+CA125在卵巢子宫内膜异位囊肿诊断中的AUC为0.952。RPR在卵巢子宫内膜异位囊肿分期中的AUC为0.713，高于PLR和SII，低于CA125；RPR+SII+CA125在卵巢子宫内膜囊肿分期预测中的AUC为0.825，敏感性为68.7%，特异性为85.7%。SII在术后2年内卵巢子宫内膜囊肿复发的AUC为0.803，高于NLR、PLR、SIRI和CA125；PLR+SII+CA125在术后2年内卵巢子宫内膜囊肿复发的AUC为0.813，敏感性为81.5%，特异性为73.0%，高于SII。结论：PLR、RPR和SII与卵巢子宫内膜囊肿的分期相关，而SII在手术后对卵巢子宫内膜囊肿的复发具有一定的预测价值。

Objective: To investigate the predictive value of platelet-to-lymphocyte ratio (PLR), red blood cell distribution width to platelet count ratio (RPR) and systemic immune inflammation index (SII) in the staging and postoperative recurrence of ovarian endometrial cysts. Methods: Retrospective analysis was made on the clinical data of patients who underwent laparoscopic surgery for ovarian cysts in the Affiliated Hospital of Qingdao University from January 2018 to January 2020. The patients with ovarian endometriosis cyst confirmed by pathology after surgery were the observation group (n=350), and the patients with other benign ovarian cyst were the control group (n=150). The preoperative platelet count, platelet distribution width, absolute number of neutrophils, lymphocyte absolute number, absolute number of monocytes, red blood cell distribution width, and serum cancer antigen 125 (CA125) of the patients in two groups were recorded, and PLR, neutrophil-to-lymphocyte ratio (NLR), RPR, SII, and systemic inflammation response index (SIRI) were calculated and analyzed. The general data of all patients and the follow-up data within 2 years after the operation of the observation group were statistically recorded to evaluate the diagnostic value of PLR, RPR and SII for ovarian endometrial cyst, and the predictive value of staging and recurrence within 2 years after the operation. Results: PLR, NLR, SII (median: 147.53, 1.86, and 488.70 respectively) and CA125 (median: 59.41 kU/L) in the observation group were significantly higher than those in the control group, while RPR (median: 0.16) was lower than that in the control group, with significant differences (all P<0.01). There was no significant difference in SIRI between the two groups (P>0.05). The PLR and SII (median: 122.73, 345.00) of the observation group at stage Ⅲ and Ⅳ were higher than those of patients at stage Ⅰ and Ⅱ, and the RPR was lower than that of patients with stage Ⅰ and Ⅱ, with significant differences (all P<0.001). The PLR, NLR, SII, SIRI (median: 179.63, 2.75, 762.96, and 1.06 respectively) and CA125 (median: 108.83 kU/L) in patients with recurrence were significantly higher than those in patients without recurrence 2 years after the operation, and the differences were statistically significant (all P<0.001). The area under curve (AUC) of CA125 in the diagnosis of ovarian endometriosis cyst was 0.951, the sensitivity was 85.7%, and the specificity was 93.0%, which were higher than those of PLR and SII; the AUC of PLR+SII+CA125 in the diagnosis of ovarian endometriosis cyst was 0.952. The AUC of RPR predicting the stage of ovarian endometriosis cyst was 0.713, higher than PLR and SII, lower than CA125; the AUC of RPR+SII+CA125 in predicting the stage of ovarian endometriotic cyst was 0.825, with sensitivity of 68.7% and specificity of 85.7%. The AUC predicted by SII for recurrence of ovarian endometriotic cyst within 2 years after the operation was 0.803, higher than NLR, PLR, SIRI and CA125; the AUC of PLR+SII+CA125, sensitivity, specificity was 0.813, 81.5% and 73.0%, higher than SII. Conclusion: PLR, RPR and SII are related to the staging of ovarian endometriotic cyst, and SII has a certain predictive value for the recurrence of ovarian endometriotic cyst after surgery.