光疗法因其微创性、可控性和空间选择性而在治疗癌症方面引起了全球的关注。一种有希望的方法是使用近红外染料IR780，该染料在808 nm激光照射下表现出光动力疗法（PDT）和光热疗法（PTT）效应。然而，这种亲水性染料的毒性和有限的肿瘤靶向能力严重制约了其在癌症应用中的适用性。在这里，我们开发了一种生物相容性纳米载体CoOOH-IR780@BSA（CoIRB），用于有效传递IR780并为结肠肿瘤提供多模式治疗。由于纳米载体的包覆，CoIRB纳米颗粒展示出可靠的分散性和稳定性，其生物毒性显著降低，以实现更安全的血液循环，克服IR780的生物屏障。这种纳米载体在体内外光疗实验中也显示出显著的效果，通过静脉注射成功抑制了MC38肿瘤的生长。此外，钴离子的引入可以诱导类芬顿反应，激活毒性羟基自由基（˙OH）的产生，发挥辅助化学动力疗法（CDT）的效果。值得注意的是，这些纳米药物还具有清除还原型谷胱甘肽（GSH）和硫化氢（H2S）的潜力，从而增强了活性氧自由基（ROS）的氧化损伤。总的来说，多功能治疗平台CoIRB为结肠癌的光动力疗法/光热疗法/化学动力疗法组合提供了重要前景的生物治疗选择。

Phototherapy has garnered worldwide attention for its minimal invasiveness, controllability, and spatial selectivity in treating cancer. One promising approach involves the use of near-infrared dye IR780, which demonstrates both photodynamic therapy (PDT) and photothermal therapy (PTT) effects under 808 nm laser irradiation. However, this hydrophobic dye's toxicity and limited tumor targeting ability severely hamper its suitability for cancer applications. Herein, a biocompatible nanoplatform CoOOH-IR780@BSA (CoIRB) is developed to efficiently deliver IR780 and provide multi-mode treatments for colon tumors. Due to the nanocarrier coating, CoIRB nanoparticles demonstrated reliable dispersion and stability, and their biotoxicity was substantially reduced for safer blood circulation, which overcame the biological barrier of IR780. The nanoplatform has also shown considerable results in phototherapy in vivo and in vitro experiments, with successful inhibition of MC38 tumor growth through intravenous administration. Additionally, the introduction of cobalt ions could induce Fenton-like reactions to activate the production of toxic hydroxyl radicals (˙OH), exerting an assisted chemodynamic therapy (CDT) effect. Notably, these nanodrugs also exhibited potential as scavengers of reductive glutathione (GSH) and hydrogen sulfide (H2S), leading to amplifying oxidative damage of reactive oxygen species (ROS). Overall, the versatile therapeutic platform, CoIRB, has opened up considerable prospects as a biotherapeutic option for combining PDT/PTT/CDT against colon cancer.