内侵入颅内静脉窦的脑膜瘤引起的静脉高压的技术考虑和介入式静脉支架置入的长期结果。
Technical considerations and long-term results of endovascular venous stenting to control venous hypertension from meningiomas invading intracranial venous sinuses.
发表日期:2023 Sep 08
作者:
J Nicholas P Higgins, Sherif R W Kirollos, Adel Helmy, Mathew R Guilfoyle, John D Pickard, Patrick R Axon, Alexis J Joannides, Sarah Jefferies, Thomas Santarius, Ramez Kirollos
来源:
JOURNAL OF NEUROSURGERY
摘要:
侵犯颅内静脉窦的脑膜瘤会导致颅内静脉高压、视乳头水肿和视力受损。然而,窦道切除和移植重建会增加肿瘤手术的复杂性,可能导致并发症的增加。本研究探讨了静脉窦支架植入是否可以提供长期控制静脉高压的可行方法。作者对于在他们机构因静脉窦受损而接受支架植入的16名脑膜瘤患者进行了回顾性分析。所有患者在就诊时都有头痛,其中9名患者伴有视乳头水肿。13名患者有1个脑膜瘤,3名患者有2个或2个以上。3名患者之前曾进行过肿瘤切除和放疗。1名患者进行过锁骨下膜室分流术和放疗。临床随访的中位时间为8年(范围为4个月至18年)。静脉窦狭窄通常不仅局限于脑膜瘤部位,而且在7名具有矢状窦脑膜瘤的患者中存在双侧横窦狭窄,类似于特发性颅内高压症所见。11名患者只在脑膜瘤引起的窦道狭窄处放置了支架。另外5名患者在同一时间在其他静脉狭窄部位也放置了支架:其中1名患者在矢状窦之前手术引起的缺损处放置了支架,在其他4名患者中,支架被放置在横窦非肿瘤狭窄处。1名患者的颈静脉也放置了支架。9名患者在脑膜瘤部位出现支架内再狭窄症状。8名患者进行了进一步的支架手术,对恢复支架腔内径的成功程度不同。剩下的一位患者出现了部分复发,正在进行复诊。所有患者在支架植入后视乳头水肿得到了缓解。6名患者经历了持久的症状缓解。5名患者在窦道腔内径恢复后仍有持续头痛。5名患者存在与难治性支架狭窄相关的持续症状。所有的诊断和治疗过程都没有出现重大并发症。对于脑膜瘤阻塞静脉窦导致症状的患者,成功放置支架可以获得良好的效果,特别是在缓解视乳头水肿方面。然而,通常需要进一步的治疗措施来保持支架通畅,其他静脉受损的情况也经常存在,并且一些患者尽管表面上成功治疗了原发病灶,但仍然有症状。长期随访是必要的。
Meningiomas invading the intracranial venous sinuses may cause intracranial venous hypertension, papilledema, and visual compromise. Sinus resection and graft reconstructions, however, add significant complexity to tumor surgery, with the potential for increased morbidity. In this study, the authors explored whether venous sinus stenting might provide an alternative means of controlling venous hypertension that would be sustainable over the long term.The authors performed a retrospective review of all 16 patients with intracranial meningiomas who underwent stenting at their institution for venous sinus compromise. At presentation, all had headache and 9 had papilledema. Thirteen patients had 1 meningioma and 3 had 2 or more. Three patients had had previous tumor resection and radiotherapy. One patient had been treated with a lumboperitoneal shunt and radiotherapy. The median length of clinical follow-up was 8 years (range 4 months-18 years).Venous sinus narrowing was often not confined to the site of meningioma, and bilateral transverse sinus narrowing, reminiscent of that seen in idiopathic intracranial hypertension, was present in 7 patients with sagittal sinus meningiomas. Eleven patients had stents placed solely across sinus narrowing caused by meningioma. Five patients had additional stents placed at other sites of venous narrowing at the same time: in one of these patients, a stent was placed across a defect in the sagittal sinus caused by previous surgery, and in the 4 other patients, stents were placed across nontumor narrowings of the transverse sinuses. In 1 patient, the jugular vein was also stented. Nine patients developed symptomatic in-stent restenosis at the meningioma site. Eight had further stenting procedures with variable success in restoring the in-stent lumen. The remaining patient, with a late partial relapse, is being reinvestigated. Papilledema resolved in all patients after stenting. Six patients experienced prolonged and very substantial relief of all symptoms. Five patients had persistent headache despite restoration of the sinus lumen. Five had persistent symptoms associated with resistant in-stent stenosis. There were no significant complications from any of the diagnostic or therapeutic procedures.In patients who are symptomatic with meningiomas obstructing the venous sinuses, successful stenting of the affected segment can give a good outcome, especially in terms of relieving papilledema. However, further procedures are often necessary to maintain stent patency, other areas of venous compromise frequently coexist, and some patients remain symptomatic despite apparently successful treatment of the index lesion. Long-term surveillance is a requirement.