芝麻酚是芝麻籽中的一种木酚素，是一种自然酚类分子，已成为一种有用的医疗剂。芝麻酚是一种无毒的植物成分，在癌症、糖尿病、心血管疾病、神经退行性疾病等的管理中发挥着一定的有价值的作用。芝麻酚通过代谢调节、对抗氧化应激、抗神经炎症等多种机制发挥其神经保护作用。然而，其口服生物利用度低、快速排泄（作为结合物）以及易受胃刺激/毒性的问题（尤其是在大鼠的前胃）可能限制了其有效性。为了克服相关限制，基于新型药物输送系统的芝麻酚制剂正兴起并得到广泛研究。这些制剂可以与芝麻酚结合，并提高游离芝麻酚的生物利用度和溶解度，并在靶位点进行输送。在本综述中，我们总结了各种研究工作，强调了芝麻酚在阿尔茨海默病、亨廷顿病、肌萎缩性侧索硬化症和帕金森病等各种神经退行性疾病中的作用。此外，还讨论了芝麻酚基纳米制剂的制备策略和神经保护作用。版权所有©2023作者。由ElsevierMasson SAS出版。保留所有权利。

Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain valuable effects in the management of cancer, diabetes, cardiovascular diseases, neurodegenerative diseases (NDs), etc. Sesamol is known to depict its neuroprotective role by various mechanisms, such as metabolic regulators, action on oxidative stress, neuroinflammation, etc. However, its poor oral bioavailability, rapid excretion (as conjugates), and susceptibility to gastric irritation/toxicity (particularly in rats' forestomach) may restrict its effectiveness. To overcome the associated limitations, novel drug delivery system-based formulations of sesamol are emerging and being researched extensively. These can conjugate with sesamol and enhance the bioavailability and solubility of free sesamol, along with delivery at the target site. In this review, we have summarized various research works highlighting the role of sesamol on various NDs, including Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, and Parkinson's disease. Moreover, the formulation strategies and neuroprotective role of sesamol-based nano-formulations have also been discussed.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.