战伯格效应是一个现象，即癌细胞在氧气存在的情况下主要依赖糖酵解而不是氧化磷酸化。尽管已发现其参与细胞增殖的证据，但战伯格效应在癌细胞在治疗中存活的优势尚未完全阐明。近年来，对放射抵抗癌细胞的代谢特征进行了评估，从而扩展了战伯格效应的原始概念。在本综述中，我们重点关注战伯格效应在氧化还原平衡和DNA损伤修复中的作用，这是放射抵抗的两个关键因素。此外，我们还强调了代谢在癌症干细胞放射抵抗中的参与，这是肿瘤复发的根本原因。最后，我们总结了针对战伯格效应的放射增敏药物。对战伯格效应和放射抵抗的分子机制的深入了解可以为提高放射治疗的疗效和成功的癌症治疗提供宝贵的信息和未来的方向。版权所有 © 2023 Elsevier B.V. 发布。

The Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect. In this review, we focused on the role of the Warburg effect in redox homeostasis and DNA damage repair, two critical factors contributing to radioresistance. In addition, we highlighted the metabolic involvement in the radioresistance of cancer stem cells, which is the root cause of tumor recurrence. Finally, we summarized radiosensitizing drugs that target the Warburg effect. Insights into the molecular mechanisms underlying the Warburg effect and radioresistance can provide valuable information for developing strategies to enhance the efficacy of radiotherapy and provide future directions for successful cancer therapy.Copyright © 2023. Published by Elsevier B.V.