本系统性回顾评估了热疗对原发、残留和复发性骨巨细胞肿瘤（GCTB）的效果。研究满足以下任一治疗方案之一的条件可纳入：射频消融（RFA），微波消融，氩气烧灼，电烧灼和热液处理。主要结局是复发。次要结局包括并发症、疼痛、功能和生活质量。微波消融作为术中刮除的辅助治疗的复发率为0％，4％和10％（3个回顾性单组研究）；氩气烧灼为4％，8％和26％（3个队列研究）；电烧灼为0％至33％（8个队列研究）；热液为9.5％和24％（2个队列研究）。随访一般≥24个月。疼痛、功能和生活质量的数据非常有限。并发症包括感染和继发性骨关节炎。目前的证据未能证明或排除热疗对GCTB复发的影响。进一步的研究应该明确（亚组的）患者是否从这些治疗中受益。

This systematic review evaluates the effects of heat treatments in de novo, residual and recurrent giant cell tumors of bone (GCTB). Studies were eligible for inclusion if one of the following treatments was administered: radiofrequency ablation (RFA), microwave ablation, argon cauterization, electrocauterization and hot liquid treatment. The primary outcome was recurrence. Secondary outcomes were complications, pain, function, and quality of life. Recurrence rates for microwave ablation as an adjuvant to intralesional curettage were 0%, 4% and 10% (3 retrospective single-group studies); for argon cauterization 4%, 8% and 26% (3 cohort studies); electrocauterization 0% to 33% (8 cohort studies); and hot liquid 9.5% and 24% (2 cohort studies). Follow-up was generally ≥24 months. Data on pain, function and quality of life were scarce. Complications included infection and secondary osteoarthritis. Current evidence does not demonstrate or exclude an effect of heat treatments on recurrence in GCTB. Further research should objectify if (subgroups of) patients benefit from these treatments.