本次荟萃分析的目的是回答以下问题：“不同口腔颌面疾病和对照组之间的欧匹鲁芬生物标志物浓度是否存在差异？”两位评审人员在七个主要数据库和三个编制灰色文献的数据库中搜索了评估欧匹鲁芬水平在口腔颌面疾病中的观察性研究。最初获取的443篇文章中，有8篇符合定量分析的纳入标准。相对百分比显示，慢性病状（烧嘴综合征，口腔潜在恶性疾病和颞下颌关节紊乱）中欧匹鲁芬浓度平均较对照组高出24.1%；持续疼痛（症状性不可逆性牙髓炎，症状性根尖周炎，疼痛的口腔软组织疾病）中欧匹鲁芬浓度平均较对照组高出33.2%；受刺激后（角膜异物，辣椒素）中欧匹鲁芬浓度平均较对照组高出21.7%。荟萃分析显示，慢性组与对照组相比，唾液中欧匹鲁芬的绝对浓度标准化均值差为0.62 [0.02, 1.22]。持续组和刺激组的对应值分别为2.24 [0.34,4.14]和0.43 [0.00,0.85]。对于“局部麻醉牙齿拔除术前”或根尖切除术，欧匹鲁芬水平没有差异。根据现有证据，总体上在口腔颌面疾病中发现了统计学上较高水平的欧匹鲁芬。唾液中的欧匹鲁芬水平在慢性、持续和急性疼痛状况中升高，这可能反映了一种生理稳态适应性反应，应激或疼痛等不同状况的反应。因此，唾液中的欧匹鲁芬可能作为多种口腔疾病的有价值的生物标志物使用。© 2023. Springer Nature Limited.

The aim of this meta-analysis was to answer the following question: "Are there any differences in opiorphin biomarker concentrations between different orofacial conditions and controls?". Two reviewers searched for observational studies that evaluated the levels of opiorphin in orofacial conditions, annotated in seven main databases and three that compile gray literature. Of the 443 articles obtained initially, 8 met the inclusion criteria for quantitative analyses. Relative percentages showed a mean 24.1% higher opiorphin concentration in chronic conditions (Burning Mouth Syndrome, Oral Potentially Malignant Diseases and Temporomandibular Disorder) compared to controls; 33.2% higher opiorphin in sustained pain (Symptomatic Irreversible Pulpitis, Symptomatic Apical Periodontitis, Painful Oral Soft-tissue conditions); and 21.7% higher opiorphin after stimuli (Corneal Foreign Body, Capsaicin). Meta-analysis revealed a standardized mean difference of 0.62 [0.02, 1.22] in the absolute concentration of opiorphin in saliva for the chronic group compared to the control. The analogous values for the sustained group and the stimulated group were 2.24 [0.34, 4.14] and 0.43 [0.00, 0.85], respectively. No differences in opiorphin levels were found for 'after Local Anesthesia before Tooth Extraction' or for apicoectomy. Based on the available evidence, in general, a statistically higher level of opiorphin is found in orofacial conditions. Salivary opiorphin levels are elevated in chronic, persisted and acute pain conditions, presumably reflecting a physiological homeostatic adaptative response to different conditions such as stress or pain. Salivary opiorphin might therefore be used as a valuable biomarker in several oral disorders.© 2023. Springer Nature Limited.