本研究旨在确定哈马丹省地下水中砷浓度与各种恶性肿瘤、先天畸形、糖尿病和阿尔茨海默病的死亡率之间的关系。收集了哈马丹省五年（2016-2020）的各种死因的死亡数据。利用极谱法在参考实验室确定了饮用水的采样方式。采用泊松回归分析了砷浓度与各种疾病死亡率之间的关系，显著水平为（p值 < 0.05）。根据泊松回归的结果，在各种死亡原因中（N = 8042），阿尔茨海默病5.94（3.67-9.61），糖尿病4.05（3.5-5.37），先天畸形2.98（1.88-4.72），乳腺癌2.72（1.56-4.71），白血病1.90（1.24-2.92），胃癌1.64（1.28-2.10），肝癌1.58（1.58-2.30），其他消化器官5.86（3.38-10.16），脑膜和脑癌1.57（1.02-2.41）与砷污染存在最高相关性。本研究结果表明，砷浓度与癌症、糖尿病、阿尔茨海默病和先天畸形的死亡率之间存在积极且显著的关系。因此，在受污染地区应采用适当的水处理方法在源头去除砷是必要的。© 2023. Springer Nature Limited.

The present study aims to determine the relationship between the concentration of arsenic in the groundwater of Hamadan province and the mortality rate due to various types of malignancies, congenital anomalies, diabetes mellitus and Alzheimer's. Mortality data due to various causes of death in Hamadan province were collected for five years (2016-2020). Sampling of drinking water was determined in the reference laboratory using polarography method. Poisson regression was used to investigate the relationship between arsenic level and the death rate due to various types of disease, at a significant level (p value < 0.05). According to the results of Poisson regression, among the various causes of death (N = 8042), Alzheimer's 5.94 (3.67-9.61), diabetes mellitus 4.05 (3.5-5.37), congenital malformations 2.98 (1.88-4.72), breast cancer 2.72 (1.56-4.71), leukemia 1.90 (1.24-2.92), stomach cancer 1.64 (1.28-2.10), Liver cancer 1.58 (1.58-2.30), other digestive organs 5.86 (3.38-10.16), meninges and brain cancer 1.57 (1.02-2.41) showed the highest relationship with arsenic contamination. The results of this study could be evidence for a positive and significant relationship between arsenic concentrations and mortality rates due to cancers, diabetes mellitus, Alzheimer disease, and congenital malformations. Therefore, it's necessary to use appropriate water treatment methods to remove arsenic at the source in contaminated areas.© 2023. Springer Nature Limited.