脂肪样增生型房间隔肥大（LHIS）是一种罕见的良性心脏疾病，其特点是脂肪组织在心房间隔中过度沉积，但却在卵圆窝处保留，形成特殊的沙漏/哑铃状结构。我们报道了一例在磁共振成像（CMR）上呈非均质特征、经过多次氟代脱氧葡萄糖正电子发射断层扫描（18F-FDG PET-CT）仍然没有氟代脱氧葡萄糖摄取（FDG uptake）的LHIS病例，与以往少数病例不同。这个单病例报告表明，当LHIS在CMR上呈现非均质特征时，代谢PET成像可以作为一个辅助的成像模型，以减少脂肪瘤的担忧，从而避免不必要的手术治疗。© 2022. 作者，独家授权给斯普林格自然出版集团下属的Springer Nature B.V。

Lipomatous hypertrophy of the interatrial septum (LHIS) is a rare benign heart disease characterized by excessive deposition of adipose tissue in the atrial septum with sparing fossa ovalis, which demonstrates a characteristic hourglass/dumbbell configuration. We reported a case of LHIS with inhomogenous characteristic on CMR and persistently no FDG uptake on 18F-FDG PET-CT, which is contrary to a few previous cases. This single case report suggests that in case LHIS present in-homogenous characteristic on CMR, metabolic PET imaging could be used as a complementary imaging model to decrease the concern of lipomatous neoplasms, thereby avoid unnecessary surgical therapy.© 2022. The Author(s), under exclusive licence to Springer Nature B.V.