丙型肝炎与肝脏脂肪变性的发展有关，从而增加了肝癌的风险。微粒体甘油三酯转运蛋白（MTTP）是一种介导脂质代谢和CD1d抗原呈递的脂质运输蛋白。本研究旨在探讨MTTP基因型（-493G/T）多态性与丙型肝炎肝脂肪变性之间的关联。检索数据库“Pubmed、Cochrane图书馆、中国知网（CNKI）、科学引文索引（Web of Science）、Embase和中国生物医学文献数据库（CBM）”以鉴定文献。使用“Newcastle-Ottawa评分”（NOS）评估所选文献的质量。使用Stata软件提取和分析相关数据。异质性以“Cochran's Q和I2”表示，其中I2≥50%或P<0.05表示高异质性。采用随机效应模型和亚组分析来确定异质性的来源。我们还使用“漏斗图”、“Egger's检验”和“Begg's检验”来评估文献中的偏倚情况。研究发现MTTP基因型（-493G/T）的显性模型与HCV基因型3的肝脂肪变性存在显著正相关（OR=11.57，95%CI: 4.467-29.962，P<0.001）。相反，肝脂肪变性与隐性、纯合或杂合模型之间没有相关性（OR=1.142，P=0.5；OR=1.581，P=0.081；OR=1.029，P=0.86）。漏斗图、Egger's检验和Begg's检验显示没有显著的出版偏倚。最后，敏感性分析表明所得结果是稳定的。MTTP基因型（-493G/T）中T等位基因的显性突变增加了HCV基因型3患者肝脂变性的易感性。 © 2023. BioMed Central Ltd., part of Springer Nature.

Hepatitis C has been associated with the development of hepatic steatosis, which increases the risk of liver cancer. The microsomal triglyceride transporter protein (MTTP), is a lipid transport protein that mediates lipid metabolism and CD1d antigen presentation. The study aimed to explore the association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C.The database "Pubmed, Cochrane library, CNKI, Web of science, Embase and CBM" were retrieved to identify the literature. The quality of the selected literature was evaluated using the "the Newcastle-Ottawa Scale" (NOS). Relevant data was extracted and analyzed using the Stata software. Heterogeneity was expressed by "Cochran's Q and I2", with I2 ≥ 50% or P < 0.05 indicating high heterogeneity. A random-effects model and subgroup analysis were conducted to identify the sources of heterogeneity. We also used "Funnel plots", "Egger's tests" and "Begg's tests" to evaluate biases in the literature.The study found a significant and positive association between liver steatosis and the HCV genotype 3 with a dominant model of the MTTP genotype (-493G/T) (OR = 11.57, 95%CI: 4.467-29.962, P < 0.001). In contrast, no correlation was found between hepatic steatosis and either the recessive, homozygous or heterozygous models (OR = 1.142, P = 0.5; OR = 1.581, P = 0.081; OR = 1.029, P = 0.86). There was no significant publication biases, as measured by the Funnel plot, and the Egger's and Begg's tests. Finally, sensitivity analysis showed the obtained results are stable.Dominant mutations in the T allele of the MTTP genotype (-493G/T) increase susceptibility to hepatic steatosis in patients presenting with the HCV genotype 3.© 2023. BioMed Central Ltd., part of Springer Nature.