化疗免疫疗法引发针对微卫星稳定结直肠癌的免疫反应。
Chemoimmunotherapy triggers immune responses targeting microsatellite stable colorectal cancer.
发表日期：2023
作者：
Marion Thibaudin, Francois Ghiringhelli
来源：
Cell Death & Disease
摘要：
免疫检查点阻断疗法改变了许多类型的癌症；然而，在转移性结直肠癌领域，检查点阻滞剂只对微卫星不稳定性肿瘤有效，而这只代表少数患者。认为微卫星稳定性肿瘤对免疫有抵抗力。最近的一项研究发表指出，与标准观点相反，化疗免疫疗法的联合可能会触发肿瘤特异性免疫应答，从而带来临床效益。© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.
Checkpoint blockade immunotherapy transforms many types of cancer; however, in the field of metastatic colorectal cancer, checkpoint blockers are only effective in microsatellite-unstable tumors, which represent only a minority of patients. Microsatellite-stable tumors are thought to be immunoresistant. A recent publication demonstrates that, contrary to the standard view point, the combination of chemo-immunotherapy could trigger a tumor-specific immune response, leading to clinical benefit.© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.